Cochrane · systematic review · CD009118
Osmotic and stimulant laxatives for the management of childhood constipation
Gordon, M, MacDonald, JK, Parker, CE, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
27
current version
GRADE rated
27
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 29.6%Low 18 · 66.7%Moderate 1 · 3.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsPEG versus placebo for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs placebo | no estimate extracted | 2 studies · 101 participants | Low Downgraded: imprecision, inconsistency |
Serious adverse events PEG vs placebo | RR 0 [0.02, 1.51] | 2 studies · 101 participants | Low Downgraded: imprecision |
PEG versus lactulose for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs lactulose | no estimate extracted | 6 studies · 465 participants | Very low Downgraded: risk of bias, inconsistency |
Need for additional therapies PEG vs lactulose | RR 0.5 [0.36, 0.83] | 4 studies · 304 participants | Low Downgraded: risk of bias, imprecision |
Successful disimpaction PEG vs lactulose | RR 0.55 [0.36, 0.83] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
Adverse events PEG vs lactulose | RR 0.8 [0.68, 1.11] | 3 studies · 242 participants | Moderate Downgraded: imprecision |
Serious adverse events PEG vs lactulose | RR 2 [0.37, 15.96] | 2 studies · 145 participants | Low Downgraded: imprecision |
PEG versus milk of magnesia (MOM) for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs milk of magnesia (MOM) | no estimate extracted | 3 studies · 211 participants | Low Downgraded: risk of bias, imprecision |
Successful disimpaction PEG vs milk of magnesia (MOM) | RR 1 [0.93, 1.16] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
PEG versus enema for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs enema | no estimate extracted | 1 study · 80 participants | Low Downgraded: risk of bias, imprecision |
S uccessful disimpaction PEG vs enema | RR 0 [0.66, 1.51] | 1 study · 90 participants | Low Downgraded: risk of bias, imprecision |
PEG versus paraffin for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs paraffin | no estimate extracted | 2 studies · 261 participants | Very low Downgraded: risk of bias, imprecision |
PEG versus flixweed for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs flixweed | no estimate extracted | 1 study · 109 participants | Low Downgraded: risk of bias, imprecision |
Need for additional therapies PEG vs flixweed | RR 3 [1.03, 12.1] | 1 study · 109 participants | Very low Downgraded: risk of bias, imprecision |
PEG versus dietary fibre for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) PEG vs dietary fibre | no estimate extracted | 1 study · 83 participants | Low Downgraded: risk of bias, imprecision |
Need for additional therapies PEG vs dietary fibre | RR 0 [0.05, 5.34] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Frequency of faecal incontinence PEG vs dietary fibre | no estimate extracted | 1 study · 83 participants | Low Downgraded: risk of bias, imprecision |
High dose PEG versus low dose PEG for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) High dose PEG vs low dose PEG | no estimate extracted | 1 study · 90 participants | Low Downgraded: risk of bias, imprecision |
Need for additional therapy High dose PEG vs low dose PEG | RR 0 [0.24, 1.02] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Faecal incontinence High dose PEG vs low dose PEG | RR 0.17 [0.02, 1.39] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events High dose PEG vs low dose PEG | RR 1 [0.33, 5.88] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Liquid paraffin (mineral oil) versus lactulose for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) Liquid paraffin (mineral oil) vs lactulose | no estimate extracted | 2 studies · 287 participants | Low Downgraded: risk of bias, imprecision |
Lactulose versus lactitol for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) Lactulose vs lactitol | no estimate extracted | 1 study · 42 participants | Low Downgraded: risk of bias, imprecision |
Lactulose versus milk of magnesia (MOM) for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) Lactulose vs milk of magnesia (MOM) | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
Successful disimpaction Lactulose vs milk of magnesia (MOM) | RR 0.83 [0.67, 1.03] | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
Need for additional therapies Lactulose vs milk of magnesia (MOM) | RR 2 [0.8, 5.02] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |
Lactulose versus partially hydrolyzed guar gum (PHGG) for the management of childhood constipation
Population: patients aged 0 to 18 years with a diagnosis of functional constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of defecation (mean number of bowel movements per week) Lactulose vs partially hydrolyzed guar gum (PHGG) | no estimate extracted | 1 study · 61 participants | Low Downgraded: risk of bias, imprecision |