Cochrane · systematic review · CD013468
Interventions for postburn pruritus
Sinha, S, Gabriel, VA, Arora, RK, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
14
No studies
10
Included studies
NR
No studies 10 · 41.7%Ungraded 0 · 0%Very low 1 · 4.2%Low 9 · 37.5%Moderate 4 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Doxepin cream vs oral antihistamine
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus (VAS) ( Doxepin cream vs oral antihistamine | no estimate extracted | 2 studies · 49 participants | Low Downgraded: risk of bias |
Adverse events (somnolence) Doxepin cream vs oral antihistamine | RR 0.64 [0.32, 1.25] | 1 study · 24 participants | Very low Downgraded: risk of bias, imprecision |
Pain Doxepin cream vs oral antihistamine | no estimate extracted | NR | No studies |
Gabapentin versus cetirizine (antihistamine)
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus (VAS) ( Gabapentin vs cetirizine (antihistamine) | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |
Adverse events (somnolence) Gabapentin vs cetirizine (antihistamine) | RR 0.02 [0, 0.38] | 1 study · 40 participants | Low Downgraded: risk of bias |
Pain Gabapentin vs cetirizine (antihistamine) | no estimate extracted | NR | No studies |
Pregabalin vs cetirizine with pheniramine maleate (antihistamine)
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus (VAS) ( Pregabalin vs cetirizine with pheniramine maleate (antihistamine) | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |
Adverse events (drowsiness) Pregabalin vs cetirizine with pheniramine maleate (antihistamine) | RR 0.04 [0, 0.69] | 1 study · 40 participants | Low Downgraded: risk of bias |
Pain Pregabalin vs cetirizine with pheniramine maleate (antihistamine) | no estimate extracted | NR | No studies |
Ondansetron vs diphenhydramine (antihistamine)
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus (NAS) ( Ondansetron vs diphenhydramine (antihistamine) | no estimate extracted | 1 study · 38 participants | Moderate Downgraded: imprecision |
Adverse events Ondansetron vs diphenhydramine (antihistamine) | no estimate extracted | NR | No studies |
Pain Ondansetron vs diphenhydramine (antihistamine) | no estimate extracted | NR | No studies |
Enalapril ointment vs placebo
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus (Scoring table for itching) ( Enalapril ointment vs placebo | no estimate extracted | 1 study · 60 participants | Moderate Downgraded: imprecision |
Adverse events Enalapril ointment vs placebo | no estimate extracted | NR | No studies |
Pain Enalapril ointment vs placebo | no estimate extracted | NR | No studies |
Massage therapy vs standard care
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus Itching scale ( Massage therapy vs standard care | no estimate extracted | 2 studies · 166 participants | Low Downgraded: risk of bias |
Adverse events Massage therapy vs standard care | no estimate extracted | NR | No studies |
Pain VAS for pain ( Massage therapy vs standard care | no estimate extracted | 2 studies · 166 participants | Low Downgraded: risk of bias |
Extracorporeal shock wave therapy vs sham
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus NRS ( Extracorporeal shock wave therapy vs sham | no estimate extracted | 2 studies · 91 participants | Low Downgraded: risk of bias |
Adverse events Extracorporeal shock wave therapy vs sham | no estimate extracted | NR | No studies |
Pain Pressure pain threshold (PPT) ( Extracorporeal shock wave therapy vs sham | MD 2.96 [1.76, 4.16] | 1 study · 45 participants | Low Downgraded: risk of bias, imprecision |
Pulsed high‐intensity laser vs placebo laser
Population: people with postburn pruritus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in burn‐related pruritus Itch Severity Scale (ISS) ( Pulsed high‐intensity laser vs placebo laser | no estimate extracted | 1 study · 49 participants | Moderate Downgraded: imprecision |
Adverse events Pulsed high‐intensity laser vs placebo laser | no estimate extracted | NR | No studies |
Pain VAS ( Pulsed high‐intensity laser vs placebo laser | no estimate extracted | 1 study · 49 participants | Moderate Downgraded: imprecision |