Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

127 questions · 131 findings · 83 reviews

No studies found 27 · 20.6%GRADE not reported 15 · 11.5%Very low 46 · 35.1%Low 23 · 17.6%Moderate 16 · 12.2%High 4 · 3.1%

Higher vs lower FiO2 or targets of arterial oxygenation

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review