Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

891 questions · 902 findings · 317 reviews

No studies found 210 · 23.3%GRADE not reported 56 · 6.2%Very low 236 · 26.2%Low 220 · 24.4%Moderate 146 · 16.2%High 34 · 3.8%

Intervention not reported

Withdrawal due to adverse events · patients with rheumatoid arthritis pain

The intervention showed no clear difference in withdrawal due to adverse events (low certainty).

1 finding from 1 review

HFNC vs standard oxygen therapy

Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ not treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ not treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Intervention not reported

Severe adverse events (≥ grade 3) · women withe low‐risk GTN

The intervention showed no clear difference in severe adverse events (≥ grade 3) (low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation for adverse events · HIV‐infected adult patients treated with a PI‐containing regimen with undetectable viral load

The intervention showed no clear difference in discontinuation for adverse events (moderate certainty).

1 finding from 1 review

Suprasorb CNP system vs the ABThera system

Adverse events (fistulae formation) · adults with an open abdomen after surgery who have not experienced trauma

It is very uncertain whether suprasorb CNP system changes adverse events (fistulae formation) compared with the ABThera system (very low certainty).

1 finding from 1 review

Intervention not reported

MST vs ECT ‐ serious adverse events · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review