Cochrane · systematic review · CD007953
Intermittent versus daily therapy for treating tuberculosis in children
Bose, A, Kalita, S, Rose, W, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intermittent short‐course anti‐TB regimens compared to daily anti‐TB regimens for treating TB in children
Population: Children with TB1
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cure Intermittent short‐course anti‐TB regimens vs daily anti‐TB regimens | RR 1.01 [0.94, 1.1] | 4 studies · 465 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Death from any cause Intermittent short‐course anti‐TB regimens vs daily anti‐TB regimens | RR 1.52 [0.26, 8.96] | 2 studies · 213 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Relapse Intermittent short‐course anti‐TB regimens vs daily anti‐TB regimens | RR 3.68 [0.15, 89.33] | 1 study · 214 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adherence to treatment Intermittent short‐course anti‐TB regimens vs daily anti‐TB regimens | RR 1.04 [0.97, 1.11] | 4 studies · 458 participants | Very low Downgraded: inconsistency, indirectness |
Treatment‐limiting adverse events Intermittent short‐course anti‐TB regimens vs daily anti‐TB regimens | RR 0.4 [0.06, 2.6] | 4 studies · 441 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |