Cochrane · systematic review · CD010248
Interleukin‐2 as maintenance therapy for children and adults with acute myeloid leukaemia in first complete remission
Mao, C, Fu, XH, Yuan, JQ, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 22.2%Very low 4 · 44.4%Low 2 · 22.2%Moderate 1 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: People with AML in first complete remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Relapses/death (instead of disease‐free survival）[2] | HR 0.95 [0.86, 1.06] | 6 studies · 1426 participants | Low Downgraded: risk of bias, imprecision |
Mortality (instead of overall survival)[2] | HR 1.05 [0.95, 1.16] | 5 studies · 1355 participants | Moderate Downgraded: risk of bias, imprecision |
Death/progress (instead of event‐free survival)[2] | HR 1.02 [0.79, 1.32] | 1 study · 161 participants | Low Downgraded: risk of bias, imprecision |
Treatment‐related mortality | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse events: hypersensitivity | RR 17.13 [0.99, 295.26] | 1 study · 528 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events: fatigue | RR 7.05 [2.13, 23.36] | 1 study · 528 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events: rigor/chills | RR 33.25 [2.01, 551.36] | 1 study · 528 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events: arthralgia/myalgia | RR 19.14 [1.12, 327.24] | 1 study · 528 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life | no estimate extracted | 0 studies · 0 participants | Ungraded |