Cochrane · systematic review · CD003113
Opioid therapy for treating rheumatoid arthritis pain
Whittle, SL, Richards, BL, Husni, E, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Opioids for rheumatoid arthritis pain
Population: patients with rheumatoid arthritis pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Patient reported global impression of clinical change (PGIC) 'good' or 'very good' PGIC scale: Very poor, Poor, No change, Good, Very good. | RR 1.44 [1.03, 2.03] | 3 studies · 324 participants | Low Downgraded: risk of bias, indirectness |
Withdrawal due to inadequate analgesia | RR 0.82 [0.34, 2.01] | 4 studies · 345 participants | Low Downgraded: risk of bias |
Functional status (HAQ) HAQ. Scale from: 0 to 3. | no estimate extracted | 2 studies · 243 participants | Low Downgraded: risk of bias |
Withdrawal due to adverse events | RR 2.67 [0.52, 13.75] | 3 studies · 331 participants | Low Downgraded: risk of bias, indirectness |
Participants reporting adverse events | OR 3.9 [2.31, 6.56] | 4 studies · 371 participants | Low Downgraded: risk of bias, indirectness |
Serious adverse events | no estimate extracted | 2 studies · 317 participants | Low Downgraded: risk of bias, imprecision |