Serious adverse events · children with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Non‐serious adverse events · children with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine showed no clear difference in non‐serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Non‐serious adverse events · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine showed no clear difference in non‐serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
In one study, one participant (<1%) in the paracetamol group experienced drug hypersensitivity (a 'red, blotchy and itchy rash') that resolved without treatment within 1 week (Bradley 2007 / McAlinden 2005); 1 RCT;…
1 study
Very low
Adverse events
It is very uncertain whether NSAIDs changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
Intervention not reported
Adverse events · people with cancer pain
1 finding from 1 review
Intervention not reported
All adverse events · patients with inflammatory arthritis on methotrexate
1 finding from 1 review
Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain
It is very uncertain whether NSAID changes neurological adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).
1 finding from 1 review
Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain
NSAID showed no clear difference in neurological adverse events compared with paracetamol (low certainty).
1 finding from 1 review
Incidence of adverse events · first aid in patients with acute oral poisoning (paracetamol or not specified)
1 finding from 1 review
Side effects or other adverse events
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain
It is very uncertain whether NSAID changes gastrointestinal adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).
1 finding from 1 review
Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain
NSAID showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty).
1 finding from 1 review
Other adverse events · people with cancer pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
Serious adverse events · people with cancer pain
1 finding from 1 review
Intervention not reported
Serious adverse events · Adults with cancer pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Serious adverse events (death) · people with cancer pain
1 finding from 1 review
Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain
1 finding from 1 review
Serious adverse events during the study period · children with acute postoperative pain
It is very uncertain whether diclofenac changes serious adverse events during study period № of participants: 60 (1… compared with paracetamol (very low certainty).
1 finding from 1 review
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found