Cochrane · systematic review · CD008872
Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Colebatch, AN, Marks, JL, Edwards, CJ · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
NSAIDs including aspirin and/or paracetamol for patients with inflammatory arthritis on methotrexate
Population: patients with inflammatory arthritis on methotrexate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pulmonary Methotrexate pneumonitis | no estimate extracted | 2 studies · 27 participants | Moderate |
Hepatic Liver histology/hepatic enzyme abnormalities2 | no estimate extracted | 2 studies · 272 participants | Low |
Renal Glomerular and tubular injury | no estimate extracted | 2 studies · 30 participants | Low |
Haematological Thrombocytopenia | no estimate extracted | 0 studies · 1 participants | Moderate |
Withdrawal due to adverse events Methotrexate discontinuation | no estimate extracted | 3 studies · 632 participants | Low |
All adverse events | no estimate extracted | 7 studies · 283 participants | Moderate |