hours
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
to 72 hours (48 hours)
Paracetamol may leads to lower to 72 hours (48 hours) compared with placebo (low certainty).
1 finding from 1 review
to 7 days
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events
It is very uncertain whether paracetamol changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
Mean time to resolution of pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mean pain score at various time points
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Reconsultations
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Delayed antibiotic prescriptions
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA
Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen (moderate certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA
Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay(by clinical… compared with ibuprofen (moderate certainty).
1 finding from 1 review
Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA
Paracetamol showed no clear difference in necrotizing enterocolitisduring initial hospital stay (by… compared with ibuprofen (moderate certainty).
1 finding from 1 review
Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA
Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with indomethacin (low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm infants with PDA
Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with indomethacin (low certainty).
1 finding from 1 review
Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm infants with PDA
Paracetamol may leads to lower necrotizing enterocolitis during initial hospital stay (by… compared with indomethacin (low certainty).
1 finding from 1 review
Mean change in pain (0–100 scale) Short term (3–12 weeks), where 0 = no pain · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in mean change in pain (0–100 scale) Short term (3–12 weeks), where 0 =… compared with placebo (high certainty).
1 finding from 1 review
Physical function · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in physical function (WOMAC function 0–100) compared with placebo (high certainty).
1 finding from 1 review
Quality of life Not measured · Patients with osteoarthritis of the knee or hip
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).
1 finding from 1 review
Total adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in total adverse events: number experiencing 24 weeks compared with placebo (high certainty).
1 finding from 1 review
Liver toxicity: number experiencing abnormal liver function tests 24 weeks · Patients with osteoarthritis of the knee or hip
Paracetamol probably leads to higher liver toxicity: number experiencing abnormal liver function tests 24… compared with placebo (moderate certainty).
1 finding from 1 review