Cochrane · systematic review · CD011534
Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute otitis media in children
de Sévaux, JL.H., Damoiseaux, RAMJ, van de Pol, AC, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
23
current version
GRADE rated
10
No studies
13
Included studies
NR
No studies 13 · 56.5%Ungraded 0 · 0%Very low 7 · 30.4%Low 3 · 13%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsParacetamol versus placebo for acute otitis media in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
hours Paracetamol vs placebo | no estimate extracted | NR | No studies |
to 72 hours (48 hours) Paracetamol vs placebo | RR 0.38 [0.17, 0.85] | 1 study · 148 participants | Low Downgraded: risk of bias, indirectness |
to 7 days Paracetamol vs placebo | no estimate extracted | NR | No studies |
Adverse events Paracetamol vs placebo | RR 1.03 [0.21, 4.93] | 1 study · 148 participants | Very low Downgraded: risk of bias, imprecision |
Mean time to resolution of pain Paracetamol vs placebo | no estimate extracted | NR | No studies |
Mean pain score at various time points Paracetamol vs placebo | no estimate extracted | NR | No studies |
Reconsultations Paracetamol vs placebo | no estimate extracted | NR | No studies |
Delayed antibiotic prescriptions Paracetamol vs placebo | no estimate extracted | NR | No studies |
NSAIDs versus placebo for acute otitis media in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
hours NSAIDs vs placebo | no estimate extracted | NR | No studies |
to 72 hours (48 hours) NSAIDs vs placebo | RR 0.28 [0.11, 0.7] | 1 study · 146 participants | Low Downgraded: risk of bias, indirectness |
to 7 days NSAIDs vs placebo | no estimate extracted | NR | No studies |
Adverse events NSAIDs vs placebo | RR 1.76 [0.44, 7.1] | 1 study · 146 participants | Very low Downgraded: risk of bias, imprecision |
Mean time to resolution of pain NSAIDs vs placebo | no estimate extracted | NR | No studies |
Mean pain score at various time points NSAIDs vs placebo | no estimate extracted | NR | No studies |
Reconsultations NSAIDs vs placebo | no estimate extracted | NR | No studies |
Delayed antibiotic prescriptions NSAIDs vs placebo | no estimate extracted | NR | No studies |
NSAIDs versus paracetamol for acute otitis media in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
hours NSAIDs vs paracetamol | RR 0.83 [0.59, 1.18] | 2 studies · 39 participants | Very low Downgraded: risk of bias, imprecision |
to 72 hours NSAIDs vs paracetamol | RR 0.91 [0.54, 1.54] | 3 studies · 183 participants | Low Downgraded: risk of bias, indirectness |
to 7 days NSAIDs vs paracetamol | RR 0.74 [0.17, 3.23] | 2 studies · 38 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events NSAIDs vs paracetamol | RR 1.71 [0.43, 6.9] | 3 studies · 281 participants | Very low Downgraded: risk of bias, imprecision |
Mean time to resolution of pain NSAIDs vs paracetamol | no estimate extracted | NR | No studies |
Reconsultations NSAIDs vs paracetamol | RR 1.13 [0.92, 1.4] | 1 study · 53 participants | Very low Downgraded: risk of bias, imprecision |
Delayed antibiotic prescriptions NSAIDs vs paracetamol | RR 1.32 [0.74, 2.35] | 1 study · 53 participants | Very low Downgraded: risk of bias, imprecision |