Cochrane · systematic review · CD015432
Ibuprofen for acute postoperative pain in children
Pessano, S, Gloeck, NR, Tancredi, L, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
8
No studies
16
Included studies
NR
No studies 16 · 66.7%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 16.7%Moderate 4 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ibuprofen compared to placebo for acute postoperative pain in children
Population: children aged 17 years or younger treated for acute postoperative or postprocedural pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention Ibuprofen vs placebo | no estimate extracted | NR | No studies |
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention Ibuprofen vs placebo | no estimate extracted | NR | No studies |
Pain intensity – as reported by the child, less than 2 hours postintervention Ibuprofen vs placebo | no estimate extracted | 3 studies · 259 participants | Moderate Downgraded: risk of bias, imprecision |
Pain intensity – as reported by the child, 2 hours to less than 24 hours postintervention Ibuprofen vs placebo | no estimate extracted | 5 studies · 345 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events (reported in the first 7 days after the procedure) Ibuprofen vs placebo | RR 0.79 [0.51, 1.23] | 5 studies · 384 participants | Low Downgraded: imprecision |
Serious adverse events (defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016)) Ibuprofen vs placebo | no estimate extracted | NR | No studies |
Ibuprofen compared to paracetamol for acute postoperative pain in children
Population: children aged 17 years or younger treated for acute postoperative or postprocedural pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention Ibuprofen vs paracetamol | no estimate extracted | NR | No studies |
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention Ibuprofen vs paracetamol | no estimate extracted | NR | No studies |
Pain intensity – as reported by the child, less than 2 hours postintervention Ibuprofen vs paracetamol | no estimate extracted | 2 studies · 100 participants | Moderate Downgraded: risk of bias, imprecision |
Pain intensity – as reported by the child, 2 hours to less than 24 hours postintervention Ibuprofen vs paracetamol | no estimate extracted | 6 studies · 422 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse events (reported in the first 7 days after the procedure) Ibuprofen vs paracetamol | no estimate extracted | 1 study · 44 participants | Low Downgraded: imprecision |
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) Ibuprofen vs paracetamol | no estimate extracted | NR | No studies |
Ibuprofen compared to morphine for acute postoperative pain in children
Population: children aged 17 years or younger treated for acute postoperative or postprocedural pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention Ibuprofen vs morphine | no estimate extracted | NR | No studies |
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention Ibuprofen vs morphine | no estimate extracted | NR | No studies |
Pain intensity – as reported by the child, less than 2 hours postintervention Ibuprofen vs morphine | no estimate extracted | NR | No studies |
Pain intensity – as reported by the child, 2 hours to less than 24 hours postintervention Ibuprofen vs morphine | no estimate extracted | NR | No studies |
Adverse events (reported in the first 7 days after the procedure) Ibuprofen vs morphine | RR 0.58 [0.4, 0.83] | 1 study · 154 participants | Moderate Downgraded: imprecision |
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) Ibuprofen vs morphine | no estimate extracted | NR | No studies |
Ibuprofen compared to ketorolac for acute postoperative pain in children
Population: children aged 17 years or younger treated for acute postoperative or postprocedural pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, less than 2 hours postintervention Ibuprofen vs ketorolac | no estimate extracted | NR | No studies |
Pain relief ‐ as reported by the child ‐ defined as proportion of participants with ≥ 50% postoperative pain relief in each treatment arm, 2 hours to less than 24 hours postintervention Ibuprofen vs ketorolac | no estimate extracted | NR | No studies |
Pain intensity – as reported by the child, less than 2 hours postintervention Ibuprofen vs ketorolac | no estimate extracted | NR | No studies |
Pain intensity – as reported by the child, 2 hours to less than 24 hours postintervention Ibuprofen vs ketorolac | no estimate extracted | NR | No studies |
Adverse events (reported in the first 7 days after the procedure) Ibuprofen vs ketorolac | no estimate extracted | 1 study · 59 participants | Low Downgraded: imprecision |
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) Ibuprofen vs ketorolac | no estimate extracted | NR | No studies |