Question · asked by 1 review
N‐acetylcysteine vs placebo: Serious adverse events
- Population
- children with non‐paracetamol (acetaminophen)‐related acute liver failure
- Intervention
- N‐acetylcysteine
- Comparison
- placebo
- Outcome
- Serious adverse events
N‐acetylcysteine showed no clear difference in serious adverse events compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
N‐acetylcysteine vs placebo Serious adverse events · children with non‐paracetamol (acetaminophen)‐related acute liver failure N‐acetylcysteine showed no clear difference in serious adverse events compared with placebo (low certainty). N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure (2020) · Cochrane Headline outcomes only | RR 1.25 [0.35, 4.51] | 1 study · 184 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- N‐acetylcysteine vs placebo · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.