Cochrane · systematic review · CD012123
N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure
Siu, JTP, Nguyen, T, Turgeon, RD · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
7
No studies
5
Included studies
NR
No studies 5 · 41.7%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 58.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
N‐acetylcysteine compared to placebo in adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
Population: adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality N‐acetylcysteine vs placebo | RR 0.88 [0.57, 1.37] | 1 study · 173 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events N‐acetylcysteine vs placebo | no estimate extracted | NR | No studies |
Liver transplant N‐acetylcysteine vs placebo | RR 0.72 [0.49, 1.06] | 1 study · 173 participants | Low Downgraded: risk of bias, imprecision |
Resolution of encephalopathy and coagulopathy N‐acetylcysteine vs placebo | no estimate extracted | NR | No studies |
Non‐serious adverse events N‐acetylcysteine vs placebo | RR 1.07 [0.79, 1.45] | 1 study · 173 participants | Low Downgraded: risk of bias, imprecision |
Quality of life N‐acetylcysteine vs placebo | no estimate extracted | NR | No studies |
N‐acetylcysteine compared to placebo in paediatric patients with non‐paracetamol (acetaminophen)‐related acute liver failure
Population: children with non‐paracetamol (acetaminophen)‐related acute liver failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality N‐acetylcysteine vs placebo | RR 1.47 [0.85, 2.53] | 1 study · 184 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events N‐acetylcysteine vs placebo | RR 1.25 [0.35, 4.51] | 1 study · 184 participants | Low Downgraded: risk of bias, imprecision |
Liver Transplant N‐acetylcysteine vs placebo | RR 1.28 [0.89, 1.84] | 1 study · 184 participants | Low Downgraded: risk of bias, imprecision |
Resolution of encephalopathy and coagulopathy ‐ not reported N‐acetylcysteine vs placebo | no estimate extracted | NR | No studies |
Non‐serious adverse events N‐acetylcysteine vs placebo | RR 1.19 [0.62, 2.16] | 1 study · 184 participants | Low Downgraded: risk of bias, imprecision |
Quality of life ‐ not reported N‐acetylcysteine vs placebo | no estimate extracted | NR | No studies |