Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

424 questions · 424 findings · 136 reviews

No studies found 93 · 21.9%GRADE not reported 14 · 3.3%Very low 130 · 30.7%Low 114 · 26.9%Moderate 58 · 13.7%High 15 · 3.5%

Intervention not reported

Serious adverse events · people with cancer pain
1 finding from 1 review

Febuxostat 40 mg/day vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Febuxostat 40 mg/day showed no clear difference in discontinuations due to adverse events compared with allopurinol (high certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Febuxostat 80 mg/day showed no clear difference in discontinuations due to adverse events compared with allopurinol (moderate certainty).

1 finding from 1 review

Febuxostat 120 mg/day vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Febuxostat 120 mg/day showed no clear difference in discontinuations due to adverse events compared with allopurinol (high certainty).

1 finding from 1 review

Cotrimoxazole vs fluoroquinolones

Other adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether cotrimoxazole changes other adverse events clinical criteria compared with fluoroquinolones (norfloxacin) (very low certainty).

1 finding from 1 review

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

Adverse events: hypotension · type 1 or type 2 diabetics

Blood pressure intervention/intensive blood pressure intervention may leads to higher adverse events—hypotension compared with placebo/standard blood pressure intervention (low certainty).

1 finding from 1 review