Cochrane · systematic review · CD013160
Single‐dose intravesical chemotherapy after nephroureterectomy for upper tract urothelial carcinoma
Hwang, EC, Sathianathen, NJ, Jung, JH, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
3
No studies
3
Included studies
NR
No studies 3 · 50%Ungraded 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Single‐dose intravesical chemotherapy instillation versus placebo or observation after nephroureterectomy for upper tract urothelial carcinoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to bladder cancer recurrence (absolute effect size estimates based on recurrence rate at 12 months) Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy | HR 0.51 [0.32, 0.82] | 2 studies · 311 participants | Low Downgraded: risk of bias |
Time to death from UTUC5 Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy | no estimate extracted | NR | No studies |
Serious adverse events Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy | no estimate extracted | 2 studies · 311 participants | Very low Downgraded: risk of bias |
Time to death from any cause5 Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy | no estimate extracted | NR | No studies |
Minor adverse events Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy | no estimate extracted | 1 study · 72 participants | Very low Downgraded: risk of bias |
Disease‐specific quality of life5 Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy | no estimate extracted | NR | No studies |