Cochrane · systematic review · CD006127

Blood pressure control for diabetic retinopathy

Do, DV, Han, G, Abariga, SA, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Eyes and Vision2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 5 · 71.4%Very low 1 · 14.3%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Blood pressure intervention/intensive blood pressure intervention compared with placebo/standard blood pressure intervention for diabetic retinopathy

Population: type 1 or type 2 diabetics
7 questions
OutcomeEffectEvidenceStatus / GRADE
Incidence of retinopathy by 5 years
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
no estimate extracted1 participantsUngraded
Progression of retinopathy by 5 years
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
no estimate extracted1 participantsUngraded
Combined incidence and progression of diabetic retinopathy by 5 years
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
no estimate extracted1 participantsUngraded
Incidence of PDR/CSME/VH by 5 years
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
no estimate extracted1 participantsUngraded
Visual acuity (loss of 3 lines or more) by 5 years
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
RR 1.15 [0.63, 2.08]2 studies · 2326 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Adverse events—all‐cause mortality
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
no estimate extracted1 participantsUngraded
Adverse events—hypotension
Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention
RR 2.04 [1.63, 2.55]2 studies · 3323 participantsLow
Downgraded: risk of bias, imprecision