Cochrane · systematic review · CD010457
Uricosuric medications for chronic gout
Kydd, ASR, Seth, R, Buchbinder, R, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
9
No studies
12
Included studies
NR
No studies 12 · 57.1%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 33.3%Moderate 2 · 9.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Benzbromarone compared with allopurinol for chronic gout
Population: people with chronic gout
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout attacks Benzbromarone vs allopurinol | RR 3.58 [0.15, 84.13] | 1 study · 55 participants | Low Downgraded: risk of bias, imprecision |
Serum urate normalisation Benzbromarone vs allopurinol | RR 1.27 [0.9, 1.79] | 2 studies · 101 participants | Moderate Downgraded: risk of bias |
Withdrawal due to adverse events Benzbromarone vs allopurinol | RR 1.25 [0.28, 5.62] | 2 studies · 91 participants | Low Downgraded: risk of bias, imprecision |
Total adverse events Benzbromarone vs allopurinol | RR 3 [0.64, 14.16] | 1 study · 55 participants | Low Downgraded: risk of bias, imprecision |
Pain reduction ‐ not measured Benzbromarone vs allopurinol | no estimate extracted | NR | No studies |
Function ‐ not measured Benzbromarone vs allopurinol | no estimate extracted | NR | No studies |
Tophus regression ‐ not reported Benzbromarone vs allopurinol | no estimate extracted | NR | No studies |
Benzbromarone compared with probenecid for chronic gout
Population: people with chronic gout
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout attacks Benzbromarone vs probenecid | RR 0.73 [0.09, 5.83] | 2 studies · 129 participants | Low Downgraded: risk of bias, imprecision |
Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) Benzbromarone vs probenecid | RR 1.43 [1.02, 2] | 1 study · 62 participants | Moderate Downgraded: risk of bias |
Withdrawal due to adverse events Benzbromarone vs probenecid | RR 0.15 [0.03, 0.79] | 2 studies · 129 participants | Low Downgraded: risk of bias, imprecision |
Total adverse events Benzbromarone vs probenecid | RR 0.43 [0.25, 0.74] | 2 studies · 129 participants | Low Downgraded: risk of bias, imprecision |
Pain Reduction ‐ not measured Benzbromarone vs probenecid | no estimate extracted | NR | No studies |
Function ‐ not measured Benzbromarone vs probenecid | no estimate extracted | NR | No studies |
Tophus regression ‐ not measured Benzbromarone vs probenecid | no estimate extracted | NR | No studies |
Probenecid compared with allopurinol for chronic gout
Population: people with chronic gout
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout attacks Probenecid vs allopurinol | RR 0.96 [0.53, 1.75] | 1 study · 37 participants | Low Downgraded: risk of bias, imprecision |
Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured Probenecid vs allopurinol | no estimate extracted | NR | No studies |
Withdrawal due to adverse events ‐ not reported Probenecid vs allopurinol | no estimate extracted | NR | No studies |
Total adverse events ‐ not reported Probenecid vs allopurinol | no estimate extracted | NR | No studies |
Pain reduction ‐ not measured Probenecid vs allopurinol | no estimate extracted | NR | No studies |
Function ‐ not measured Probenecid vs allopurinol | no estimate extracted | NR | No studies |
Tophus regression ‐ not reported Probenecid vs allopurinol | no estimate extracted | NR | No studies |