Cochrane · systematic review · CD010156

Dietary supplements for chronic gout

Andrés, M, Sivera, F, Buchbinder, R, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Musculoskeletal2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 6 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 8 · 57.1%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Skim milk enriched with GMP/G600 compared with skim milk, plus lactose powder for chronic gout

Population: people with chronic gout

7 questions

Outcome	Effect	Evidence	Status / GRADE
Acute gout flaresParticipant self‐report, using gout flare diary Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	no estimate extracted	1 study · 120 participants	Low Downgraded: risk of bias, imprecision
Study withdrawals due to adverse events Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	RR 1.27 [0.53, 3.03]	1 study · 120 participants	Low Downgraded: risk of bias, imprecision
sUA acid reductionb (in mmol/L) Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	no estimate extracted	1 study · 120 participants	Low Downgraded: risk of bias, imprecision
Joint pain reduction10‐point Likert scale (0 = no pain) Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	no estimate extracted	1 study · 120 participants	Low Downgraded: risk of bias, imprecision
Participant global assessment 5‐point Likert scale (5 = excellent) Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	no estimate extracted	NR	No studies
Total adverse eventsd Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	RR 0.97 [0.66, 1.45]	1 study · 120 participants	Low Downgraded: risk of bias, imprecision
Tophus regression Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder	no estimate extracted	NR	No studies

Vitamin C compared with allopurinol for chronic gout

Population: peoeple with chronic gout and sUA level > 0.36 mmol/L

7 questions

Outcome	Effect	Evidence	Status / GRADE
Acute gout flares Vitamin C vs allopurinol	no estimate extracted	NR	No studies
Study withdrawals due to adverse events Vitamin C vs allopurinol	no estimate extracted	1 study · 40 participants	Low Downgraded: risk of bias, imprecision
sUA reduction Vitamin C vs allopurinol	no estimate extracted	1 study · 40 participants	Low Downgraded: risk of bias, imprecision
Joint pain reduction Vitamin C vs allopurinol	no estimate extracted	NR	No studies
Participant global assessment Vitamin C vs allopurinol	no estimate extracted	NR	No studies
Total adverse events Vitamin C vs allopurinol	no estimate extracted	1 study · 40 participants	Low Downgraded: risk of bias, imprecision
Tophus regression Vitamin C vs allopurinol	no estimate extracted	NR	No studies