Cochrane · systematic review · CD010156
Dietary supplements for chronic gout
Andrés, M, Sivera, F, Buchbinder, R, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
8
No studies
6
Included studies
NR
No studies 6 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 8 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySkim milk enriched with GMP/G600 compared with skim milk, plus lactose powder for chronic gout
Population: people with chronic gout
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout flaresParticipant self‐report, using gout flare diary Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Study withdrawals due to adverse events Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | RR 1.27 [0.53, 3.03] | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
sUA acid reductionb (in mmol/L) Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Joint pain reduction10‐point Likert scale (0 = no pain) Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Participant global assessment 5‐point Likert scale (5 = excellent) Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | no estimate extracted | NR | No studies |
Total adverse eventsd Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | RR 0.97 [0.66, 1.45] | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Tophus regression Skim milk enriched with GMP/G600 vs skim milk, plus lactose powder | no estimate extracted | NR | No studies |
Vitamin C compared with allopurinol for chronic gout
Population: peoeple with chronic gout and sUA level > 0.36 mmol/L
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout flares Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Study withdrawals due to adverse events Vitamin C vs allopurinol | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
sUA reduction Vitamin C vs allopurinol | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Joint pain reduction Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Participant global assessment Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Total adverse events Vitamin C vs allopurinol | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Tophus regression Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Skim milk enriched with GMP/G600 compared with skim milk plus lactose powder for chronic gout
Population: people with chronic gout
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout attack frequency Participant self report using gout flare diary Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Participant withdrawals due to adverse events Participant and study investigator‐reported Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | RR 1.27 [0.53, 3.03] | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Joint pain reduction 10‐point Likert scale Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Physical function HAQ‐II questionnaire. Scale 0‐3; 0 = no disability. Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Tophus regression ‐ not measured Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | no estimate extracted | NR | No studies |
sUA acid reduction4 ‐ mmol/L at Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | no estimate extracted | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Participant and study investigator‐reported5 Skim milk enriched with GMP/G600 vs skim milk plus lactose powder | RR 1.33 [0.23, 7.66] | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Vitamin C compared with allopurinol for chronic gout
Population: participants with chronic gout and sUA level > 0.36mmol/L
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute gout attack frequency ‐ not reported Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Participant withdrawals due to adverse events Vitamin C vs allopurinol | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |
Joint pain reduction ‐ not reported Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Physical function ‐ not reported Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
Tophus regression ‐ not measured Vitamin C vs allopurinol | no estimate extracted | NR | No studies |
sUA reduction Vitamin C vs allopurinol | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |
Adverse events Vitamin C vs allopurinol | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |