Non-Cochrane · DTA;prognostic · PM42122240
Diagnostic and Prognostic Significance of Chemokines in Head and Neck Cancers: A Systematic Review and Meta-Analysis.
Alsheikh Raneem, Assami Deemah, Nasrallah Dima, et al. · Cancers · 2026 · PubMed · doi:10.3390/cancers18091437
Findings
Population Patients with head and neck cancers
3 findings
| High serum IL-8 | Low serum IL-8 | Overall survival Overall survival · Serum samples; OSCC, NPC, laryngeal cancer | HR 1.88 [0.72, 4.92] GRADE not reported 4 studies |
| High CXCL10 | Low CXCL10 | Overall survival Overall survival · Serum and tissue samples; OSCC, NPC, HNSCC, TSCC | HR 0.79 [0.43, 1.47] GRADE not reported 6 studies |
| High CXCR4 expression | Low CXCR4 expression | Overall survival Overall survival · Tissue samples; OSCC, NPC, HNSCC, TSCC | HR 1.53 [0.55, 4.24] GRADE not reported 4 studies |
Included primary studies 76
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Wang 2021 matched by author and year (probable) | NR | 4 other reviews | Overall survival | not extracted yet |
| Wang 2024 matched by author and year (probable) | NR | 3 other reviews | not stated | not extracted yet |
| Ghallab 2017 Serum and salivary levels of chemerin and MMP-9 in oral squamous cell carcinoma and oral premalignant lesions. PMID:27161218 | 2017 | 2 other reviews | not stated | not extracted yet |
| Singh 2020 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Wang 2019 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Chen 2024 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Lee 2018 Evaluation of saliva and plasma cytokine biomarkers in patients with oral squamous cell carcinoma. PMID:29174861 | 2018 | 1 other review | not stated | not extracted yet |
| St John 2004 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Tang 2015 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Adamov 2024 Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma DOI:10.1080/13102818.2024.2423777 | 2024 | this review only | not stated | not extracted yet |
| Adamov 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Allen 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Allen 2007 Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma. PMID:17545521 | 2007 | this review only | not stated | not extracted yet |
| Chang 2008 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chang 2008 Macrophage inflammatory protein-3alpha is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes. PMID:18980993 | 2008 | this review only | not stated | not extracted yet |
| Chang 2011 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Chang 2011 Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival. PMID:21560180 | 2011 | this review only | Overall survival | not extracted yet |
| Chang 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chang 2013 Serum levels of chemokine (C-X-C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral… PMID:23769451 | 2013 | this review only | not stated | not extracted yet |
| Chen 2024 CXCL8, MMP12, and MMP13 are common biomarkers of periodontitis and oral squamous cell carcinoma. PMID:36321868 | 2024 | this review only | not stated | not extracted yet |
| Cheng 2014 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Cheng 2014 Prognostic value of interleukin-8 and MMP-9 in nasopharyngeal carcinoma. PMID:23749058 | 2014 | this review only | Overall survival | not extracted yet |
| De-Colle 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| De-Colle 2017 SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. PMID:29594214 | 2017 | this review only | not stated | not extracted yet |
| De-Colle 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| De-Colle 2018 SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary… PMID:29061496 | 2018 | this review only | not stated | not extracted yet |
| Dikova 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Dikova 2021 Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma. PMID:33924500 | 2021 | this review only | not stated | not extracted yet |
| Domingueti 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Domingueti 2019 Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth. PMID:31011147 | 2019 | this review only | not stated | not extracted yet |
| Economopoulou 2019 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Economopoulou 2019 Surrogates of immunologic cell death (ICD) and chemoradiotherapy outcomes in head and neck squamous cell carcinoma (HNSCC). PMID:31178219 | 2019 | this review only | Overall survival | not extracted yet |
| Fujita 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fujita 2014 Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell… PMID:25461761 | 2014 | this review only | not stated | not extracted yet |
| Ghallab and Shaker 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gleber-Netto 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gleber-Netto 2016 Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population. PMID:26847061 | 2016 | this review only | not stated | not extracted yet |
| Hamad 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hao 2013 Prognostic value of interleukin-6 and interleukin-8 in laryngeal squamous cell cancer. PMID:23269580 | 2013 | this review only | not stated | not extracted yet |
| Huang 2022 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Huang 2022 High Expression of Interferon Pathway Genes CXCL10 and STAT2 Is Associated with Activated T-Cell Signature and Better Outcome of Oral… PMID:35207629 | 2022 | this review only | Overall survival | not extracted yet |
| Jotic 2022 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Jotic 2022 Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer. PMID:35898723 | 2022 | this review only | Overall survival | not extracted yet |
| Lee 2009 Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma. PMID:19272813 | 2009 | this review only | Overall survival | not extracted yet |
| Li 2020 Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma. PMID:33489879 | 2020 | this review only | Overall survival | not extracted yet |
| Li 2022 CCR5 as a prognostic biomarker correlated with immune infiltrates in head and neck squamous cell carcinoma by bioinformatic study. PMID:36167571 | 2022 | this review only | not stated | not extracted yet |
| Long 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Long 2025 Multiparameter diagnostic model using S100A9, CCL5 and blood biomarkers for nasopharyngeal carcinoma. PMID:40033021 | 2025 | this review only | not stated | not extracted yet |
| Lou 2025 CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway. PMID:40629333 | 2025 | this review only | Overall survival | not extracted yet |
| Lu 2011 Serum CCL2 and serum TNF-α--two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in… PMID:20951575 | 2011 | this review only | not stated | not extracted yet |
| Mao 2018 Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid… PMID:29295705 | 2018 | this review only | not stated | not extracted yet |
| Mao 2020 CCL18 overexpression predicts a worse prognosis in oral squamous cell carcinoma (OSCC). PMID:32202908 | 2020 | this review only | not stated | not extracted yet |
| Rajkumar 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Rajkumar 2014 Validation of the diagnostic utility of salivary interleukin 8 in the differentiation of potentially malignant oral lesions and oral… PMID:24950604 | 2014 | this review only | not stated | not extracted yet |
| Rentoft 2014 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Rentoft 2014 Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue. PMID:24395654 | 2014 | this review only | Overall survival | not extracted yet |
| Schiegnitz 2018 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Schiegnitz 2018 Proinflammatory cytokines as serum biomarker in oral carcinoma-A prospective multi-biomarker approach. PMID:29272054 | 2018 | this review only | Overall survival | not extracted yet |
| Shen 2022 matched by author and year (probable) | NR | this review only | Overall survival | not extracted yet |
| Shen 2022 Expression profile and prognostic value of CXCR family members in head and neck squamous cell carcinoma. PMID:35978426 | 2022 | this review only | Overall survival | not extracted yet |
| Singh 2020 Validation of Salivary Markers, IL-1β, IL-8 and Lgals3bp for Detection of Oral Squamous Cell Carcinoma in an Indian Population. PMID:32355279 | 2020 | this review only | not stated | not extracted yet |
| St John 2004 Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. PMID:15313862 | 2004 | this review only | not stated | not extracted yet |
| Sun 2011 Duffy antigen receptor for chemokines in laryngeal squamous cell carcinoma as a negative regulator. PMID:21105847 | 2011 | this review only | not stated | not extracted yet |
| Susha 2023 Evaluation of salivary Chemerin in oral leukoplakia, oral squamous cell carcinoma and healthy controls DOI:10.4103/jofs.jofs_40_23 | 2023 | this review only | not stated | not extracted yet |
| Susha and Ravindran 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tang 2015 Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma. PMID:26634210 | 2015 | this review only | not stated | not extracted yet |
| Tao 2016 Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma. PMID:26611644 | 2016 | this review only | Overall survival | not extracted yet |
| Tsuzuki 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tsuzuki 2006 Oral and oropharyngeal squamous cell carcinomas expressing CCR7 have poor prognoses. PMID:16223574 | 2006 | this review only | not stated | not extracted yet |
| Wang 2019 CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer. PMID:30395826 | 2019 | this review only | not stated | not extracted yet |
| Wang 2021 Key genes affecting the progression of nasopharyngeal carcinoma identified by RNA-sequencing and bioinformatic analysis. PMID:34544905 | 2021 | this review only | Overall survival | not extracted yet |
| Wang 2024 Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer. PMID:38246983 | 2024 | this review only | not stated | not extracted yet |
| Yanagiya 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yanagiya 2021 Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma. PMID:33783897 | 2021 | this review only | not stated | not extracted yet |
| Zergoun 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zergoun 2022 Plasma secretome analyses identify IL-8 and nitrites as predictors of poor prognosis in nasopharyngeal carcinoma patients. PMID:35278812 | 2022 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients or samples with confirmed head and neck cancers | Patients with head and neck cancers (OSCC, NPC, OPSCC, LSCC, HNSCC, TSCC); 7294 participants from 17 countries (n=44 studies) |
| Intervention | Chemokines as diagnostic or prognostic biomarkers | Chemokines and receptors (IL-8, CXCL10, CXCR4, MIP-3a, chemerin and others) in serum, saliva, plasma and tissue |
| Comparison | Not specified | Not specified |
| Outcomes | Diagnostic accuracy (sensitivity, specificity); hazard ratios for OS, DFS, DMFS, DSS, MFS, CSS, PFS, RFS, LRC | Pooled OS hazard ratios for serum IL-8 (n=4), CXCL10 (n=6) and CXCR4 (n=4); diagnostic sensitivity and specificity reported narratively (no pooling) |
| Study designs | Observational studies; English language; original articles | 44 observational studies (32 prognostic, 14 diagnostic) |
| Timing | Not specified | Not specified |