Non-Cochrane · intervention · PM41936654
The effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review.
Sodnom-Ish Buyanbileg, Kühl Sebastian, Herber Valentin, et al. · International journal of implant dentistry · 2026 · PubMed · doi:10.1186/s40729-026-00680-8
Findings
Population Patients receiving dental implants, with serum vitamin D status assessed
3 findings
| Vitamin D sufficient status | Low vitamin D status (insufficient or deficient) | Early dental implant failure (EDIF) Early healing (up to 12 months) · Dental implant treatment | RR 1.87 [1.01, 3.45] GRADE not reported 5 studies · 1739 participants |
| Vitamin D sufficient status | Low vitamin D status (insufficient or deficient) | Early marginal bone loss (MBL) change Up to 12 months · Dental implant treatment | MD -0.33 [-0.44, -0.23] GRADE not reported 2 studies · 102 participants |
| Vitamin D sufficient status | Low vitamin D status (insufficient or deficient) | Implant stability quotient (ISQ) 3 months · Dental implant treatment | MD 4.37 [0.41, 8.33] GRADE not reported 2 studies · 106 participants |
Included primary studies 46
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Singh 2020 matched by author and year (probable) | NR | 2 other reviews | Early dental implant failure (EDIF); PM41936654-P2-O1 | not extracted yet |
| Acipinar 2019 Evaluation of FGF‐23 and 25(OH)D <sub>3</sub> levels in peri‐implant sulcus fluid in peri‐implant health and diseases DOI:10.1111/cid.12832 | 2019 | this review only | not stated | not extracted yet |
| Acipinar 2019 Evaluation of FGF-23 and 25(OH)D3 levels in peri-implant sulcus fluid in peri-implant health and diseases. PMID:31407857 | 2019 | this review only | not stated | not extracted yet |
| Al-Quisi 2024 Relationship Between the Level of Vitamin D3 Deficiency and Successful Osseointegration: A Prospective Clinical Study DOI:10.1155/2024/9933646 | 2024 | this review only | Early dental implant failure (EDIF) | not extracted yet |
| Al-Quisi 2024 Relationship Between the Level of Vitamin D3 Deficiency and Successful Osseointegration: A Prospective Clinical Study. PMID:39376220 | 2024 | this review only | PM41936654-P2-O1 | not extracted yet |
| Bhandage 2022 Evaluation of Correlation between Vitamin D Levels and Implant Stability in Indian Population: A Prospective Study in Bangalore DOI:10.1007/s12663-021-01579-0 | 2021 | this review only | not stated | not extracted yet |
| Bhandage 2022 Evaluation of Correlation between Vitamin D Levels and Implant Stability in Indian Population: A Prospective Study in Bangalore. PMID:36274890 | 2022 | this review only | not stated | not extracted yet |
| Cheng 2024 Hypervitaminosis D is correlated with adverse dental implant outcomes: A retrospective case-control study DOI:10.1016/j.jdent.2024.105137 | 2024 | this review only | not stated | not extracted yet |
| Cheng 2024 Hypervitaminosis D is correlated with adverse dental implant outcomes: A retrospective case-control study. PMID:38901822 | 2024 | this review only | not stated | not extracted yet |
| Diachkova 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Dulinska-Litewka 2025 Influence of the soft tissue thickness and the levels of vitamin D3 as important factors in bone preservation around the dental implant… DOI:10.17219/dmp/179004 | 2025 | this review only | not stated | not extracted yet |
| Dulinska-Litewka 2025 Influence of the soft tissue thickness and the levels of vitamin D3 as important factors in bone preservation around the dental implant… PMID:40644203 | 2025 | this review only | not stated | not extracted yet |
| Francis 2024 The Relationship of Low-Serum Vitamin D and Early Dental Implant Failure DOI:10.1563/aaid-joi-d-23-00168 | 2024 | this review only | not stated | not extracted yet |
| Francis 2024 The Relationship of Low-Serum Vitamin D and Early Dental Implant Failure. PMID:38530826 | 2024 | this review only | not stated | not extracted yet |
| Garg 2020 Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin… PMID:33897181 | 2020 | this review only | not stated | not extracted yet |
| Ghasemi 2022 Effect of vitamin B complex administration on pain and sensory problems related to inferior alveolar nerve damage following mandibular… PMID:35919449 | 2022 | this review only | not stated | not extracted yet |
| Grigoras 2025 The Impact of LDL Cholesterol, HDL Cholesterol, Triglycerides, and Vitamin D on Short-Term Implant Survival Rate: A Prospective… PMID:40429527 | 2025 | this review only | Early dental implant failure (EDIF); PM41936654-P2-O1 | not extracted yet |
| Iqbal 2024 Effect of Vitamin D in Dental Implants Osseointegration – A Randomized Controlled Trial DOI:10.58397/ashkmdc.v29i4.981 | 2024 | this review only | not stated | not extracted yet |
| Kwiatek 2021 Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site… DOI:10.3390/jcm10030526 | 2021 | this review only | not stated | not extracted yet |
| Kwiatek 2021 Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site… PMID:33540512 | 2021 | this review only | not stated | not extracted yet |
| Li 2018 Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic periodontitis DOI:10.1111/cid.12647 | 2018 | this review only | not stated | not extracted yet |
| Li 2018 Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic… PMID:30039526 | 2018 | this review only | not stated | not extracted yet |
| Mangano 2016 Is Low Serum Vitamin D Associated with Early Dental Implant Failure? A Retrospective Evaluation on 1625 Implants Placed in 822 Patients DOI:10.1155/2016/5319718 | 2016 | this review only | Early dental implant failure (EDIF) | not extracted yet |
| Mangano 2016 Is Low Serum Vitamin D Associated with Early Dental Implant Failure? A Retrospective Evaluation on 1625 Implants Placed in 822 Patients. PMID:27738389 | 2016 | this review only | PM41936654-P2-O1 | not extracted yet |
| Mangano 2018 Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885… DOI:10.15171/joddd.2018.027 | 2018 | this review only | not stated | not extracted yet |
| Mangano 2018 Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885… PMID:30443302 | 2018 | this review only | not stated | not extracted yet |
| Mohsen 2024 Is Vitamin D Deficiency a Risk Factor for Osseointegration of Dental Implants - A Prospective Study. PMID:39184430 | 2024 | this review only | Early dental implant failure (EDIF); PM41936654-P2-O1 | not extracted yet |
| Paz 2021 DOI:10.3290/j.ohpd.b2082063 | NR | this review only | not stated | not extracted yet |
| Paz 2021 Vitamin D Deficiency and Early Implant Failure: Outcomes from a Pre-surgical Supplementation Program on Vitamin D Levels and Antioxidant… PMID:34585875 | 2021 | this review only | not stated | not extracted yet |
| Piccolotto 2019 Effect of Vitamin D Supplementation on Clinical and Radiographic Evaluation of Oral Rehabilitation with Osseointegrated Implants DOI:10.17921/2447-8938.2019v21n5p518-522 | 2019 | this review only | not stated | not extracted yet |
| Piccolotto 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Schulze-Spate 2016 Systemic vitamin <scp>D</scp> supplementation and local bone formation after maxillary sinus augmentation – a randomized, double‐blind,… DOI:10.1111/clr.12641 | 2015 | this review only | not stated | not extracted yet |
| Schulze-Spate 2017 Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation - a randomized, double-blind,… PMID:26178580 | 2016 | this review only | not stated | not extracted yet |
| Singh 2023 Correlation of Serum Vitamin D with Crestal Bone Level in Dental Implant Patients Using CBCT: A Clinical Retrospective Study DOI:10.5005/jp-journals-10024-3537 | 2023 | this review only | not stated | not extracted yet |
| Singh 2023 Correlation of Serum Vitamin D with Crestal Bone Level in Dental Implant Patients Using CBCT: A Clinical Retrospective Study. PMID:37622616 | 2023 | this review only | not stated | not extracted yet |
| Singh 2025 Vitamin - D supplements for better osteointegration in dental implant surgery: A randomized control trial. PMID:40822803 | 2025 | this review only | not stated | not extracted yet |
| Tabrizi 2022 Does the serum level of vitamin D affect marginal bone loss around dental implants? DOI:10.1016/j.ijom.2021.11.006 | 2022 | this review only | Early marginal bone loss (MBL) change | not extracted yet |
| Tabrizi 2022 Does the serum level of vitamin D affect marginal bone loss around dental implants? PMID:34872836 | 2022 | this review only | PM41936654-P2-O2 | not extracted yet |
| Toy 2024 Resonance frequency analysis of dental implants in patients with vitamin D deficiency DOI:10.1007/s00784-024-06085-4 | 2024 | this review only | Implant stability quotient (ISQ) | not extracted yet |
| Toy 2024 Resonance frequency analysis of dental implants in patients with vitamin D deficiency. PMID:39630320 | 2024 | this review only | Implant stability quotient (ISQ) | not extracted yet |
| Toy 2025 Vitamin‐D Insufficiency Leads to Interleukin‐10 Reduction in Peri‐Implant Tissues: A Case–Control Study DOI:10.1111/cid.13425 | 2025 | this review only | Implant stability quotient (ISQ); Early marginal bone loss (MBL) change | not extracted yet |
| Toy 2025 (case-control) Vitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-Implant Tissues: A Case-Control Study. PMID:39930521 | 2025 | this review only | Implant stability quotient (ISQ); PM41936654-P2-O2 | not extracted yet |
| Ustaoglu 2020 Relationship between risk markers for cardiovascular disease and peri-implant diseases DOI:10.1186/s40729-020-00273-z | 2020 | this review only | not stated | not extracted yet |
| Ustaoglu 2020 Relationship between risk markers for cardiovascular disease and peri-implant diseases. PMID:33236168 | 2020 | this review only | not stated | not extracted yet |
| Wach 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wach 2024 Bone Metabolism and Dental Implant Insertion as a Correlation Affecting on Marginal Bone Remodeling: Texture Analysis and the New… PMID:38892923 | 2024 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human patients receiving dental implant treatment regardless of age or sex, with systemic nutritional status, dietary intake or supplementation assessed | Dental implant patients (27 studies; 24 on vitamin D, 1 vitamin B, 1 vitamin C) |
| Intervention | Dental implant installation in patients with defined dietary or micronutrient status | Sufficient or supplemented vitamin D status; vitamin B complex; vitamin C supplementation |
| Comparison | Dental implant placement in patients with different nutritional statuses | Low vitamin D status; control groups |
| Outcomes | ISQ; early dental implant failure; implant survival/success; implant failure; marginal bone loss; clinical attachment level, probing depth, bleeding index | ISQ (n=7); EDIF (n=5); short-term MBL (n=7); bone density (n=2); soft tissue (n=5); long-term outcomes (n=5) |
| Study designs | Human clinical studies (trials and observational), English language | 13 cohort, 8 RCTs, 3 cross-sectional, 2 case-control, 1 uncontrolled interventional study |
| Timing | Not specified | Early outcomes up to 12 months; long-term up to 19 years |