Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Diagnostic and Prognostic Significance of Chemokines in Head and Neck Cancers: A Systematic Review and Meta-Analysis.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Wang 2021 matched by author and year (probable) | NR | 5 | 1 | not extracted yet |
| Wang 2024 matched by author and year (probable) | NR | 4 | none stated | not extracted yet |
| Serum and salivary levels of chemerin and MMP-9 in oral squamous cell carcinoma and oral premalignant lesions. Ghallab 2017 · Ghallab Noha A, Shaker Olfat G · Clinical oral investigations PMID:27161218 | 2017 | 3 | none stated | not extracted yet |
| Singh 2020 matched by author and year (probable) | NR | 3 | 2 | not extracted yet |
| Wang 2019 matched by author and year (probable) | NR | 3 | 1 | not extracted yet |
| Evaluation of saliva and plasma cytokine biomarkers in patients with oral squamous cell carcinoma. Lee 2018 · Lee L T, Wong Y K, et al. · International journal of oral and maxillofacial surgery PMID:29174861 | 2018 | 2 | none stated | not extracted yet |
| Chen 2024 matched by author and year (probable) | NR | 2 | 1 | not extracted yet |
| St. John et al. 2004 matched by author and year (probable) | NR | 2 | 1 | not extracted yet |
| Tang et al. 2015 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Multiparameter diagnostic model using S100A9, CCL5 and blood biomarkers for nasopharyngeal carcinoma. Long 2025 · Long Lu, Tao Ya, et al. · Scientific reports PMID:40033021 | 2025 | 1 | none stated | not extracted yet |
| CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway. Lou 2025 · Lou Huiquan, Xia Yichao, et al. · Journal of translational medicine PMID:40629333 | 2025 | 1 | 1 | not extracted yet |
| Cytokines levels in saliva in periodontitis, oral potentially malignant disorders and squamous cell carcinoma Adamov 2024 · Adamov Angel, Bolyarova-Konova Teodora, et al. · Biotechnology & Biotechnological Equipment DOI:10.1080/13102818.2024.2423777 | 2024 | 1 | none stated | not extracted yet |
| CXCL8, MMP12, and MMP13 are common biomarkers of periodontitis and oral squamous cell carcinoma. Chen 2024 · Chen Xin, Lei Hao, et al. · Oral diseases PMID:36321868 | 2024 | 1 | none stated | not extracted yet |
| Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer. Wang 2024 · Wang Weihua, Ruan Suyu, et al. · Clinical and experimental otorhinolaryngology PMID:38246983 | 2024 | 1 | none stated | not extracted yet |
| Evaluation of salivary Chemerin in oral leukoplakia, oral squamous cell carcinoma and healthy controls Susha 2023 · Susha Karthika Pradeep, Ravindran Rathy · Journal of Orofacial Sciences DOI:10.4103/jofs.jofs_40_23 | 2023 | 1 | none stated | not extracted yet |
| High Expression of Interferon Pathway Genes CXCL10 and STAT2 Is Associated with Activated T-Cell Signature and Better Outcome of Oral Cancer Patients. Huang 2022 · Huang Yun-Cian, Huang Jau-Ling, et al. · Journal of personalized medicine PMID:35207629 | 2022 | 1 | 1 | not extracted yet |
| Plasma secretome analyses identify IL-8 and nitrites as predictors of poor prognosis in nasopharyngeal carcinoma patients. Zergoun 2022 · Zergoun Ahmed Amine, Draleau Kyle S, et al. · Cytokine PMID:35278812 | 2022 | 1 | none stated | not extracted yet |
| Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer. Jotic 2022 · Jotic Ana, Milovanovic Jovica, et al. · Dose-response : a publication of International Hormesis Society PMID:35898723 | 2022 | 1 | 1 | not extracted yet |
| Expression profile and prognostic value of CXCR family members in head and neck squamous cell carcinoma. Shen 2022 · Shen Yiming, Zhou Chongchang, et al. · World journal of surgical oncology PMID:35978426 | 2022 | 1 | 1 | not extracted yet |
| CCR5 as a prognostic biomarker correlated with immune infiltrates in head and neck squamous cell carcinoma by bioinformatic study. Li 2022 · Li Chunhong, Chen Shanlin, et al. · Hereditas PMID:36167571 | 2022 | 1 | none stated | not extracted yet |
| Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma. Yanagiya 2021 · Yanagiya Misa, Dawood Randa I H, et al. · Pathology international PMID:33783897 | 2021 | 1 | none stated | not extracted yet |
| Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma. Dikova 2021 · Dikova Valentina, Jantus-Lewintre Eloisa, et al. · Journal of clinical medicine PMID:33924500 | 2021 | 1 | none stated | not extracted yet |
| Key genes affecting the progression of nasopharyngeal carcinoma identified by RNA-sequencing and bioinformatic analysis. Wang 2021 · Wang Yihong, Li Manyi, et al. · Aging PMID:34544905 | 2021 | 1 | 1 | not extracted yet |
| CCL18 overexpression predicts a worse prognosis in oral squamous cell carcinoma (OSCC). Mao 2020 · Mao L, Zhuang R, et al. · Neoplasma PMID:32202908 | 2020 | 1 | none stated | not extracted yet |
| Validation of Salivary Markers, IL-1β, IL-8 and Lgals3bp for Detection of Oral Squamous Cell Carcinoma in an Indian Population. Singh 2020 · Singh Prerana, Verma Jitendra K, et al. · Scientific reports PMID:32355279 | 2020 | 1 | none stated | not extracted yet |
| Analysis of the Prognosis and Therapeutic Value of the CXC Chemokine Family in Head and Neck Squamous Cell Carcinoma. Li 2020 · Li Yongchao, Wu Tinghui, et al. · Frontiers in oncology PMID:33489879 | 2020 | 1 | 1 | not extracted yet |
| CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer. Wang 2019 · Wang Lei, Zhang Mei, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons PMID:30395826 | 2019 | 1 | none stated | not extracted yet |
| Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth. Domingueti 2019 · Domingueti C-B, Janini J-B-M, et al. · Medicina oral, patologia oral y cirugia bucal PMID:31011147 | 2019 | 1 | none stated | not extracted yet |
| Surrogates of immunologic cell death (ICD) and chemoradiotherapy outcomes in head and neck squamous cell carcinoma (HNSCC). Economopoulou 2019 · Economopoulou Panagiota, Koutsodontis George, et al. · Oral oncology PMID:31178219 | 2019 | 1 | 1 | not extracted yet |
| SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy. De-Colle 2018 · De-Colle Chiara, Menegakis Apostolos, et al. · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology PMID:29061496 | 2018 | 1 | none stated | not extracted yet |
| Proinflammatory cytokines as serum biomarker in oral carcinoma-A prospective multi-biomarker approach. Schiegnitz 2018 · Schiegnitz Eik, Kämmerer Peer W, et al. · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology PMID:29272054 | 2018 | 1 | 1 | not extracted yet |
| Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid… Mao 2018 · Mao Min-Jie, Xue Ning, et al. · BMC cancer PMID:29295705 | 2018 | 1 | none stated | not extracted yet |
| SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy. De-Colle 2017 · De-Colle Chiara, Mönnich David, et al. · Clinical and translational radiation oncology PMID:29594214 | 2017 | 1 | none stated | not extracted yet |
| Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma. Tao 2016 · Tao Hengmin, Wei Yumei, et al. · Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine PMID:26611644 | 2016 | 1 | 1 | not extracted yet |
| Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population. Gleber-Netto 2016 · Gleber-Netto Frederico Omar, Yakob Maha, et al. · Clinical cancer research : an official journal of the American Association for Cancer Research PMID:26847061 | 2016 | 1 | none stated | not extracted yet |
| Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma. Tang 2015 · Tang Minzhong, Ou Ningjiang, et al. · BioMed research international PMID:26634210 | 2015 | 1 | none stated | not extracted yet |
| Prognostic value of interleukin-8 and MMP-9 in nasopharyngeal carcinoma. Cheng 2014 · Cheng Daye, Kong Hong, et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery PMID:23749058 | 2014 | 1 | 1 | not extracted yet |
| Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue. Rentoft 2014 · Rentoft Matilda, Coates Philip John, et al. · Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine PMID:24395654 | 2014 | 1 | 1 | not extracted yet |
| Validation of the diagnostic utility of salivary interleukin 8 in the differentiation of potentially malignant oral lesions and oral squamous cell… Rajkumar 2014 · Rajkumar K, Nandhini G, et al. · Oral surgery, oral medicine, oral pathology and oral radiology PMID:24950604 | 2014 | 1 | none stated | not extracted yet |
| Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma. Fujita 2014 · Fujita Yohei, Okamoto Masato, et al. · PloS one PMID:25461761 | 2014 | 1 | none stated | not extracted yet |
| Prognostic value of interleukin-6 and interleukin-8 in laryngeal squamous cell cancer. Hao 2013 · Hao Wenwei, Zhu Yongping, et al. · Medical oncology (Northwood, London, England) PMID:23269580 | 2013 | 1 | none stated | not extracted yet |
| Serum levels of chemokine (C-X-C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral cavity… Chang 2013 · Chang Kai-Ping, Wu Chih-Ching, et al. · Oral oncology PMID:23769451 | 2013 | 1 | none stated | not extracted yet |
| Serum CCL2 and serum TNF-α--two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in nasopharyngeal… Lu 2011 · Lu Xing, Qian Chao-Nan, et al. · European journal of cancer (Oxford, England : 1990) PMID:20951575 | 2011 | 1 | none stated | not extracted yet |
| Duffy antigen receptor for chemokines in laryngeal squamous cell carcinoma as a negative regulator. Sun 2011 · Sun Guohua, Wang Yu, et al. · Acta oto-laryngologica PMID:21105847 | 2011 | 1 | none stated | not extracted yet |
| Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival. Chang 2011 · Chang Kai-Ping, Chang Ya-Ting, et al. · Head & neck PMID:21560180 | 2011 | 1 | 2 | not extracted yet |
| Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma. Lee 2009 · Lee Jae-Il, Jin Bo-Hyong, et al. · Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics PMID:19272813 | 2009 | 1 | 1 | not extracted yet |
| Macrophage inflammatory protein-3alpha is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes. Chang 2008 · Chang Kai-Ping, Hao Sheng-Po, et al. · Clinical cancer research : an official journal of the American Association for Cancer Research PMID:18980993 | 2008 | 1 | none stated | not extracted yet |
| Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma. Allen 2007 · Allen Clint, Duffy Sonia, et al. · Clinical cancer research : an official journal of the American Association for Cancer Research PMID:17545521 | 2007 | 1 | none stated | not extracted yet |
| Oral and oropharyngeal squamous cell carcinomas expressing CCR7 have poor prognoses. Tsuzuki 2006 · Tsuzuki Hideaki, Takahashi Noboru, et al. · Auris, nasus, larynx PMID:16223574 | 2006 | 1 | none stated | not extracted yet |
| Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. St John 2004 · St John Maie A R, Li Yang, et al. · Archives of otolaryngology--head & neck surgery PMID:15313862 | 2004 | 1 | none stated | not extracted yet |