Non-Cochrane · DTA · PM41726192
Efficacy of CBCT and Conventional Radiography in Identifying Bone Invasion in Oral Cancer - A Comparative Systematic Review.
Pillai Vedika, Nisa Shams Ul, Mhapuskar Amit, et al. · Annals of maxillofacial surgery · 2025 · PubMed · doi:10.4103/ams.ams_80_25
Findings
Population Patients with oral squamous cell carcinoma undergoing preoperative imaging for bone invasion
3 findings
| Cone-beam computed tomography (CBCT) | Conventional radiography (panoramic or periapical); reference standard histopathology or intraoperative findings | Diagnostic odds ratio Preoperative imaging of OSCC | Diagnostic OR (4 studies, subset); inconsistent across studies Moderate Downgraded: imprecision, inconsistency 4 studies |
| Cone-beam computed tomography (CBCT) | Conventional radiography (panoramic or periapical); reference standard histopathology or intraoperative findings | Sensitivity (summary AUC) Preoperative imaging of OSCC | AUC 0.59 Low Downgraded: risk of bias, imprecision, inconsistency 9 studies |
| Cone-beam computed tomography (CBCT) | Conventional radiography (panoramic or periapical); reference standard histopathology or intraoperative findings | Specificity Preoperative imaging of OSCC | Specificity (60%-100%); generally high across studies High 9 studies |
Included primary studies 26
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Wang 2021 matched by author and year (probable) | NR | 4 other reviews | not stated | not extracted yet |
| Ramesh 2020 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Islam 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Aslan 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Czerwonka 2017 High-resolution cone-beam computed tomography for assessment of bone invasion in oral cancer: Comparison with conventional computed… DOI:10.1002/hed.24858 | 2017 | this review only | not stated | not extracted yet |
| Czerwonka 2017 High-resolution cone-beam computed tomography for assessment of bone invasion in oral cancer: Comparison with conventional computed… PMID:28703386 | 2017 | this review only | not stated | not extracted yet |
| Hendrikx 2010 Cone-beam CT in the assessment of mandibular invasion by oral squamous cell carcinoma: results of the preliminary study DOI:10.1016/j.ijom.2010.02.008 | 2010 | this review only | not stated | not extracted yet |
| Hendrikx 2010 Cone-beam CT in the assessment of mandibular invasion by oral squamous cell carcinoma: results of the preliminary study. PMID:20211543 | 2010 | this review only | not stated | not extracted yet |
| Hosen 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kolk 2014 Combined SPECT/CT improves detection of initial bone invasion and determination of resection margins in squamous cell carcinoma of the… DOI:10.1007/s00259-014-2726-6 | 2014 | this review only | not stated | not extracted yet |
| Kolk 2014 Combined SPECT/CT improves detection of initial bone invasion and determination of resection margins in squamous cell carcinoma of the… PMID:24573657 | 2014 | this review only | not stated | not extracted yet |
| Kouketsu 2021 Comparison of different diagnostic imaging techniques for the detection of bone invasion in oral cancers DOI:10.1016/j.oraloncology.2021.105453 | 2021 | this review only | not stated | not extracted yet |
| Kouketsu 2021 Comparison of different diagnostic imaging techniques for the detection of bone invasion in oral cancers. PMID:34265573 | 2021 | this review only | not stated | not extracted yet |
| Kuduva Ramesh 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Linz 2015 Performance of cone beam computed tomography in comparison to conventional imaging techniques for the detection of bone invasion in oral… DOI:10.1016/j.ijom.2014.07.023 | 2015 | this review only | not stated | not extracted yet |
| Linz 2015 Performance of cone beam computed tomography in comparison to conventional imaging techniques for the detection of bone invasion in oral… PMID:25442744 | 2015 | this review only | not stated | not extracted yet |
| Nascimento 2018 Comparison of panoramic radiography and cone beam CT in the assessment of juxta-apical radiolucency DOI:10.1259/dmfr.20170198 | 2018 | this review only | not stated | not extracted yet |
| Nascimento 2018 Comparison of panoramic radiography and cone beam CT in the assessment of juxta-apical radiolucency. PMID:28871830 | 2018 | this review only | not stated | not extracted yet |
| Ramis-Alario 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shenoy 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shimizu 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Slieker 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Straub 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Takeshita 2014 Evaluation of diagnostic accuracy of conventional and digital periapical radiography, panoramic radiography, and cone-beam computed… DOI:10.4103/0976-237x.137930 | 2014 | this review only | not stated | not extracted yet |
| Takeshita 2014 Evaluation of diagnostic accuracy of conventional and digital periapical radiography, panoramic radiography, and cone-beam computed… PMID:25191066 | 2014 | this review only | not stated | not extracted yet |
| Waghmare 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with OSCC undergoing preoperative imaging | OSCC patients (sample sizes 14 to 197); some included studies on MRONJ, periapical lesions or in vitro bone loss |
| Intervention | Index tests: CBCT and/or conventional panoramic/periapical radiography | CBCT; CT; MRI; PET/CT; SPECT/CT; panoramic and periapical radiography |
| Comparison | Histopathology or intraoperative findings as reference standard | Histopathology or surgical findings |
| Outcomes | Sensitivity, specificity, PPV, NPV, accuracy for bone invasion | Sensitivity, specificity, accuracy, summary AUC 0.59 |
| Study designs | Comparative or observational studies (cross-sectional, case-control, cohort) | Diagnostic accuracy studies (n=19) |
| Timing | Not specified | Not specified |