Non-Cochrane · aetiology · PM41917210
Serum lipid alterations in oral squamous cell carcinoma and oral potentially malignant disorders: A systematic review and meta-analysis.
Kishor Shreeja, Rankovic Mila Janjic, Otto Sven, et al. · Scientific reports · 2026 · PubMed · doi:10.1038/s41598-026-46163-z
Findings
15 findings
| Population | ||||
|---|---|---|---|---|
| Patients with oral squamous cell carcinoma (OSCC) and healthy controls | Oral squamous cell carcinoma (OSCC) | Healthy controls | Serum Triglycerides (TGs) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.83 [0.37, 1.28] GRADE not reported 35 studies |
| Patients with oral squamous cell carcinoma (OSCC) and healthy controls | Oral squamous cell carcinoma (OSCC) | Healthy controls | Serum Low-density lipoprotein cholesterol (LDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.96 [0.42, 1.51] GRADE not reported 34 studies |
| Patients with oral squamous cell carcinoma (OSCC) and healthy controls | Oral squamous cell carcinoma (OSCC) | Healthy controls | Serum High-density lipoprotein cholesterol (HDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 1.97 [1.08, 2.85] GRADE not reported 37 studies · 3604 participants |
| Patients with oral squamous cell carcinoma (OSCC) and healthy controls | Oral squamous cell carcinoma (OSCC) | Healthy controls | Serum Total cholesterol (TC) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 1.55 [0.95, 2.15] GRADE not reported 37 studies · 3604 participants |
| Patients with oral squamous cell carcinoma (OSCC) and healthy controls | Oral squamous cell carcinoma (OSCC) | Healthy controls | Serum Very low-density lipoprotein cholesterol (VLDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.82 [0.09, 1.56] GRADE not reported 29 studies |
| Patients with oral potentially malignant disorders (OPMD) and healthy controls | Oral potentially malignant disorders (OPMD) | Healthy controls | Serum Triglycerides (TGs) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.69 [0.25, 1.14] GRADE not reported 29 studies |
| Patients with oral potentially malignant disorders (OPMD) and healthy controls | Oral potentially malignant disorders (OPMD) | Healthy controls | Serum Very low-density lipoprotein cholesterol (VLDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.60 [0.05, 1.16] GRADE not reported 27 studies |
| Patients with oral potentially malignant disorders (OPMD) and healthy controls | Oral potentially malignant disorders (OPMD) | Healthy controls | Serum Low-density lipoprotein cholesterol (LDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.75 [0.24, 1.26] GRADE not reported 28 studies |
| Patients with oral potentially malignant disorders (OPMD) and healthy controls | Oral potentially malignant disorders (OPMD) | Healthy controls | Serum Total cholesterol (TC) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 1.37 [0.86, 1.88] GRADE not reported 31 studies · 2527 participants |
| Patients with oral potentially malignant disorders (OPMD) and healthy controls | Oral potentially malignant disorders (OPMD) | Healthy controls | Serum High-density lipoprotein cholesterol (HDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 1.47 [0.81, 2.12] GRADE not reported 31 studies · 2527 participants |
| Patients with oral squamous cell carcinoma (OSCC) and patients with oral potentially malignant disorders (OPMD) | Oral squamous cell carcinoma (OSCC) | Oral potentially malignant disorders (OPMD) | Serum Low-density lipoprotein cholesterol (LDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 1.13 [0.05, 2.20] GRADE not reported 13 studies |
| Patients with oral squamous cell carcinoma (OSCC) and patients with oral potentially malignant disorders (OPMD) | Oral squamous cell carcinoma (OSCC) | Oral potentially malignant disorders (OPMD) | Serum High-density lipoprotein cholesterol (HDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.18 [-0.60, 0.96] GRADE not reported 16 studies · 1446 participants |
| Patients with oral squamous cell carcinoma (OSCC) and patients with oral potentially malignant disorders (OPMD) | Oral squamous cell carcinoma (OSCC) | Oral potentially malignant disorders (OPMD) | Serum Triglycerides (TGs) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.76 [-0.04, 1.55] GRADE not reported 15 studies |
| Patients with oral squamous cell carcinoma (OSCC) and patients with oral potentially malignant disorders (OPMD) | Oral squamous cell carcinoma (OSCC) | Oral potentially malignant disorders (OPMD) | Serum Total cholesterol (TC) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.62 [0.08, 1.16] GRADE not reported 16 studies · 1446 participants |
| Patients with oral squamous cell carcinoma (OSCC) and patients with oral potentially malignant disorders (OPMD) | Oral squamous cell carcinoma (OSCC) | Oral potentially malignant disorders (OPMD) | Serum Very low-density lipoprotein cholesterol (VLDL) level Cross-sectional (single measurement) · Hospital-based case-control studies, mostly India (47 of 52) | SMD 0.66 [-0.14, 1.47] GRADE not reported 12 studies |
Included primary studies 90
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Kumar 2013 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Ramesh 2020 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Agrawal 2021 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Singh 2013 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Singh 2021 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Acharya 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Acharya 2016 Serum lipid profile in oral squamous cell carcinoma: alterations and association with some clinicopathological parameters and tobacco use. PMID:26899131 | 2016 | this review only | not stated | not extracted yet |
| Adnan 2023 Alterations of Serum Lipids Profiles in Patients with Head and Neck Cancers DOI:10.23937/2378-3419/1410181 | 2023 | this review only | not stated | not extracted yet |
| Agarwal 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Agarwal 2015 Exploratory Study to Evaluate Changes in Serum Lipid Levels as Early Diagnostic and/or Prognostic Indicators for Oral Submucous Fibrosis… PMID:26434856 | 2015 | this review only | not stated | not extracted yet |
| Ajai 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ajai 2014 Estimation of serum lipids in patients with Oral Submucous Fibrosis in India. PMID:25136423 | 2014 | this review only | not stated | not extracted yet |
| Alazzawi 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Alazzawi 2022 The evaluation of serum lipid profile and apolipoprotein C-1 in the Iranian patients of Oral Squamous Cell Carcinoma. PMID:36381193 | 2022 | this review only | not stated | not extracted yet |
| Anand 2018 Alteration in serum lipid profile pattern in oral cancer and oral submucous fibrosis patients DOI:10.4103/jiaomr.jiaomr_88_17 | 2018 | this review only | not stated | not extracted yet |
| Anand 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Anuradha 2013 Lipid Profile in Oropharyngeal Cancers in Southern India DOI:10.6000/1929-2279.2013.02.02.3 | 2013 | this review only | not stated | not extracted yet |
| Anuradha 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Banseria 2014 CORRELATION OF SERUM LIPID PROFILE, SERUM CALCIUM, ALKALINE PHOSPHATASE AND SERUM PROTEIN WITH HISTOPATHOLOGICAL GRADING AND STAGING IN… DOI:10.14260/jemds/2014/2090 | 2014 | this review only | not stated | not extracted yet |
| Banseria 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bhagat 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bhagat 2017 PMID:54912017 | NR | this review only | not stated | not extracted yet |
| Chandra 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chandra 2025 Comparison of haematological and serum lipid profile parameters in oral potentially malignant disorders and oral squamous cell carcinoma. PMID:41019684 | 2025 | this review only | not stated | not extracted yet |
| Chawda 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chawda 2011 The relationship between serum lipid levels and the risk of oral cancer. PMID:21731214 | 2011 | this review only | not stated | not extracted yet |
| Chowdhury 2022 LIPID PROFILE ESTIMATION IN ORAL MALIGNANT AND PREMALIGNANT LESIONS DOI:10.36106/ijsr/3609104 | 2022 | this review only | not stated | not extracted yet |
| Dongre 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ganavi 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ganavi 2014 Evaluation of serum lipids and lipoproteins as prognosticators in leukoplakia. PMID:25307809 | 2014 | this review only | not stated | not extracted yet |
| Garg 2014 Serum lipid profile in oral precancer and cancer: a diagnostic or prognostic marker? PMID:24876700 | 2014 | this review only | not stated | not extracted yet |
| Garg 2014 PMID:62332014 | NR | this review only | not stated | not extracted yet |
| Goel 2014 Lipid profile in oral potentially malignant disorders DOI:10.4103/0972-1363.155633 | 2014 | this review only | not stated | not extracted yet |
| Goel 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gupta 2011 Alterations in serum lipid profile patterns in oral cancer and oral precancerous lesions and conditions—a clinical study DOI:10.1016/s0975-962x(11)60002-6 | 2011 | this review only | not stated | not extracted yet |
| Gupta 2011 Molecular dynamic behavior and binding affinity of flavonoid analogues to the cyclin dependent kinase 6/cyclin D complex. PMID:22172011 | 2012 | this review only | not stated | not extracted yet |
| Kamath 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kamath 2014 Risk factors, lipid profile, and histopathological study of oral cancers in Kolar district: a case-control study. PMID:24762506 | 2014 | this review only | not stated | not extracted yet |
| Kanthem 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kanthem 2015 Serum lipid profile in oral submucous fibrosis: A clinico pathological study. PMID:26604487 | 2015 | this review only | not stated | not extracted yet |
| Khyalia 2022 A Comparative Study of Serum Lipid Profile in Patients with Oral Squamous Cell Carcinoma and Healthy Population in a Tertiary Health Care… DOI:10.31557/apjcb.2022.7.3.239-244 | 2022 | this review only | not stated | not extracted yet |
| Khyalia 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kumar 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kumar 2012 Serum lipid profile in oral cancer and leukoplakia: correlation with tobacco abuse and histological grading. PMID:23174719 | 2012 | this review only | not stated | not extracted yet |
| Kumar 2013 Alteration in plasma lipid profile in oral submucous fibrosis patients: A case control study. PMID:24455599 | 2013 | this review only | not stated | not extracted yet |
| Li 2016 Alteration of serum lipid profile and its prognostic value in head and neck squamous cell carcinoma. PMID:26189546 | 2016 | this review only | not stated | not extracted yet |
| Lohe 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lohe 2010 Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. PMID:20002982 | 2010 | this review only | not stated | not extracted yet |
| Mahesh 2014 Alterations of Plasma lipid profile patterns in oral leukoplakia. PMID:24653608 | 2014 | this review only | not stated | not extracted yet |
| Mahesh 2014 PMID:61782014 | NR | this review only | not stated | not extracted yet |
| Mehta 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mehta 2014 Serum lipid profile in patients with oral cancer and oral precancerous conditions. PMID:25097644 | 2014 | this review only | not stated | not extracted yet |
| Mujoo 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nayak 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Neerupakam 2014 Alterations in plasma lipid profile patterns in oral cancer DOI:10.4103/0972-1363.145004 | 2014 | this review only | not stated | not extracted yet |
| Neerupakam 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Patel 2004 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Patel 2004 Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. PMID:15105576 | 2004 | this review only | not stated | not extracted yet |
| Poorey 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Poorey 2016 Alteration of Lipid Profile in Patients with Head and Neck Malignancy. PMID:27340626 | 2016 | this review only | not stated | not extracted yet |
| Pratap 2018 Estimation of serum lipid profile in patients with OSMF DOI:10.4103/jiaomr.jiaomr_21_17 | 2018 | this review only | not stated | not extracted yet |
| Pratap 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Qian 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Qian 2023 Clinical relevance of serum lipids in the carcinogenesis of oral squamous cell carcinoma. PMID:37013557 | 2023 | this review only | not stated | not extracted yet |
| Radhakrishna 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Radhakrishna M.D.S 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ramesh 2020 Evaluation of serum lipid profile and complete hemogram in patients with oral submucous fibrosis: A case control study DOI:10.4103/jioh.jioh_308_19 | 2020 | this review only | not stated | not extracted yet |
| Rashmi 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Reddy 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Reddy 2016 Analysis of lipid profile in cancer patients, smokers, and nonsmokers. PMID:28182070 | 2016 | this review only | not stated | not extracted yet |
| Sachin 2022 DOI:10.9756/int-jecse/v14i4.68 | NR | this review only | not stated | not extracted yet |
| Sai 2022 Lipid profile in oral potentially malignant disorders and oral squamous cell carcinoma - A prognostic view. PMID:37082055 | 2022 | this review only | not stated | not extracted yet |
| Sasankoti 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Siddique 2021 Evaluation of Serum Lipid Profile in Patients Suffering from Oral Submucous Fibrosis DOI:10.53350/pjmhs2115102793 | 2021 | this review only | not stated | not extracted yet |
| Siddique 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Singh 2013 Alterations in serum lipid profile patterns in oral cancer. PMID:24082735 | 2013 | this review only | not stated | not extracted yet |
| Singh 2021 Diagnostic significance of serum and salivary lipid levels in oral precancer and oral cancer. PMID:34483575 | 2021 | this review only | not stated | not extracted yet |
| Srinivas 2013 Evaluation and correlation of serum lipid profile in oral and gastrointestinal cancer patients. PMID:24453448 | 2013 | this review only | not stated | not extracted yet |
| Srinivas 2013 PMID:56722013 | NR | this review only | not stated | not extracted yet |
| Swamy 2017 Alterations of serum lipid profile in oral submucous fibrosis DOI:10.18203/issn.2454-5929.ijohns20174334 | 2017 | this review only | not stated | not extracted yet |
| Swamy 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Varshney 2023 Study of serum lipid profile in patients of oral squamous cell carcinoma DOI:10.4103/jdrysruhs.jdrysruhs_4_21 | 2023 | this review only | not stated | not extracted yet |
| Varshney 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vijay 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vikram 2022 Biochemical profile alterations of lipids in oral submucous fibrosis DOI:10.33545/26174693.2022.v6.i2b.149 | 2022 | this review only | not stated | not extracted yet |
| Vyas 2016 Comparative Study of Serum Lipid Profile Parameters for Oral Cancer and Non Oral Cancer Patients DOI:10.21276/ijchmr.2016.2.2.08 | 2106 | this review only | not stated | not extracted yet |
| Vyas 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vyas 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yashveer 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yashveer 2018 Alteration of Serum Lipid in Oral Sub Mucous Fibrosis in Central India. PMID:30211101 | 2018 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with OSCC or OPMD (leukoplakia, erythroplakia, oral submucous fibrosis, lichen planus) and matched healthy controls | OSCC (n=1855) vs controls (n=1749) in 37 studies; OPMD (n=1398) vs controls (n=1129) in 31 studies; OSCC (n=701) vs OPMD (n=745) in 16 studies |
| Intervention | Quantitative assessment of serum lipid parameters (TC, LDL, HDL, VLDL, TGs) | Serum TC, HDL, LDL, VLDL, TGs (n=52 studies) |
| Comparison | Healthy controls without oral cancer, precancerous lesions or other head and neck malignancy | Healthy controls; OPMD as comparator for OSCC |
| Outcomes | Alterations in serum lipid profile | Reduced TC, HDL, LDL, VLDL and TGs in OSCC and OPMD vs controls; OSCC vs OPMD differed for TC and LDL |
| Study designs | Case-control studies with at least 30 participants, peer-reviewed, English | Case-control studies (n=52); 47 from India, 2 China, 1 each Pakistan, Syria, Iran |
| Timing | Not specified | Not specified |