Non-Cochrane · aetiology · PM41744919
Periodontitis and Oral and Oropharyngeal Cancer Risk: A Systematic Review and Meta-Analysis with Exploratory Evidence on Tumor-Associated Porphyromonas gingivalis.
Chauca-Bajaña Luis, Sánchez Arteaga Bernarda Andrea, Ordóñez Balladares Andrea, et al. · Dentistry journal · 2026 · PubMed · doi:10.3390/dj14020080
Findings
6 findings
| Population | ||||
|---|---|---|---|---|
| Adults aged 18 years or older | Clinically defined periodontitis (exposure) | No periodontitis or periodontally healthy | Risk, incidence or mortality of oral and/or oropharyngeal cancer Leave-one-out sensitivity analysis (range of pooled estimates) | Pooled risk estimates ranged approximately from RR about 1.9 to 2.6 after sequential exclusion of each study, remaining above unity GRADE not reported 5 studies |
| Adults aged 18 years or older | Clinically defined periodontitis (exposure) | No periodontitis or periodontally healthy | Risk, incidence or mortality of oral and/or oropharyngeal cancer | HR 2.14 [1.53, 2.98] GRADE not reported 6 studies |
| Adults with histopathologically confirmed oral squamous cell carcinoma | Presence or high intratumoral expression of Porphyromonas gingivalis | P. gingivalis negative or low expression | Overall survival | HR 2.89 [1.93, 4.32] GRADE not reported 3 studies |
| Adults with histopathologically confirmed oral squamous cell carcinoma | Presence or high intratumoral expression of Porphyromonas gingivalis | P. gingivalis negative or low expression | Overall survival Leave-one-out sensitivity analysis: omitting Guo et al. 2021 | HR 2.44 [1.47, 4.04] GRADE not reported 2 studies |
| Adults with histopathologically confirmed oral squamous cell carcinoma | Presence or high intratumoral expression of Porphyromonas gingivalis | P. gingivalis negative or low expression | Overall survival Leave-one-out sensitivity analysis: omitting Li et al. 2024 | HR 3.50 [2.05, 5.96] GRADE not reported 2 studies |
| Adults with histopathologically confirmed oral squamous cell carcinoma | Presence or high intratumoral expression of Porphyromonas gingivalis | P. gingivalis negative or low expression | Overall survival Leave-one-out sensitivity analysis: omitting Wen et al. 2020 | HR 2.89 [1.71, 4.90] GRADE not reported 2 studies |
Included primary studies 9
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Moergel 2013 Chronic periodontitis and its possible association with oral squamous cell carcinoma - a retrospective case control study. PMID:24321243 | 2013 | 2 other reviews | Risk, incidence or mortality of oral and/or oropharyngeal cancer | not extracted yet |
| Divaris 2010 Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study. PMID:20049634 | 2010 | 1 other review | Risk, incidence or mortality of oral and/or oropharyngeal cancer | not extracted yet |
| Guo 2021 Bioinformatics and immunohistochemistry analyses of expression levels and clinical significance of CXCL2 and TANs in an oral squamous cell… PMID:33574928 | 2021 | 1 other review | Overall survival | not extracted yet |
| Laprise 2016 Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. PMID:27215979 | 2016 | 1 other review | Risk, incidence or mortality of oral and/or oropharyngeal cancer | not extracted yet |
| Li 2024 Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral… PMID:38671413 | 2024 | 1 other review | Overall survival | not extracted yet |
| Shin 2019 Association of Periodontitis with Oral Cancer: A Case-Control Study. PMID:30779879 | 2019 | 1 other review | Risk, incidence or mortality of oral and/or oropharyngeal cancer | not extracted yet |
| Tezal 2007 Chronic periodontitis and the risk of tongue cancer. PMID:17515503 | 2007 | 1 other review | Risk, incidence or mortality of oral and/or oropharyngeal cancer | not extracted yet |
| Wen 2014 Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. PMID:24336850 | 2014 | this review only | Risk, incidence or mortality of oral and/or oropharyngeal cancer | not extracted yet |
| Wen 2020 Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment. PMID:32298192 | 2020 | this review only | Overall survival | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Arm 1: adults aged 18 years or older; Arm 2: adults with histopathologically confirmed oral and/or oropharyngeal cancer | Arm 1: adults (6 studies; USA, Germany, Taiwan, India, South Korea); Arm 2: adults with oral squamous cell carcinoma (3 studies; China) |
| Intervention | Arm 1: clinically defined periodontitis; Arm 2: presence or higher burden of tumor-associated periodontal pathogens (P. gingivalis, F. nucleatum, T. forsythia, T. denticola) | Arm 1: periodontitis by radiographic bone loss, clinical examination, self-report, ICD code or health records (n=6); Arm 2: intratumoral P. gingivalis by IHC or PCR (n=3) |
| Comparison | Arm 1: no periodontitis or periodontally healthy; Arm 2: no pathogen detected or low bacterial load | Arm 1: no periodontitis or gingivitis only; Arm 2: Pg-negative, low or weak expression |
| Outcomes | Arm 1: risk, incidence or mortality of oral and/or oropharyngeal cancer (HR, OR, RR); Arm 2: overall survival, disease-free, progression-free and recurrence-free survival | Arm 1: oral and/or oropharyngeal cancer risk (pooled HR 2.14); Arm 2: overall survival (pooled HR 2.89) |
| Study designs | Arm 1: cohort, case-control and population-based studies; Arm 2: cohort and translational studies with follow-up | Arm 1: 4 case-control and 2 cohort studies; Arm 2: 3 retrospective cohorts |
| Timing | Not specified | Not specified |