evidencegaps
Primary study · included by 2 reviews

Bioinformatics and immunohistochemistry analyses of expression levels and clinical significance of CXCL2 and TANs in an oral squamous cell carcinoma tumor microenvironment of Prophyromonas gingivalis infection.

Guo 2021 · Guo Zhi-Chen, Jumatai Sakendeke, Jing Si-Li, et al. · Oncology letters · 2021

Included by

Periodontitis and Oral and Oropharyngeal Cancer Risk: A Systematic Review and Meta-Analysis with Exploratory Evidence on Tumor-Associated Porphyromonas gingivalis.
Non-Cochrane · aetiology · 2026 · cited as Guo 2021 · Table 1; Table 2; Reference list
Outcome this study informsPooled effectEvidenceCertainty
Overall survival
Presence or high intratumoral expression of Porphyromonas gingivalis vs P. gingivalis negative or low expression
HR 2.44 [1.47, 4.04]2 studiesGRADE not reported
Overall survival
Presence or high intratumoral expression of Porphyromonas gingivalis vs P. gingivalis negative or low expression
HR 2.89 [1.93, 4.32]3 studiesGRADE not reported
Overall survival
Presence or high intratumoral expression of Porphyromonas gingivalis vs P. gingivalis negative or low expression
HR 3.50 [2.05, 5.96]2 studiesGRADE not reported
Overall survival
Presence or high intratumoral expression of Porphyromonas gingivalis vs P. gingivalis negative or low expression
HR 2.89 [1.71, 4.90]2 studiesGRADE not reported
Periodontal Disease and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Risk and Survival Outcomes.
Non-Cochrane · prognostic · 2026 · cited as Guo 2021 · Tables 1 and 2; reference list
Outcome this study informsPooled effectEvidenceCertainty
Overall survival
High intratumoral Porphyromonas gingivalis expression vs Low or weak intratumoral P. gingivalis expression
HR 2.15 [1.33, 3.47]2 studiesVery low
Overall survival
High intratumoral Porphyromonas gingivalis expression vs Low or weak intratumoral P. gingivalis expression
HR 2.15 [1.33, 3.47]2 studiesGRADE not reported

2 including reviews in total.