Non-Cochrane · prognostic · PM42074964
Periodontal Disease and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Risk and Survival Outcomes.
Zambrano Manzaba Gabriela Guadalupe, Chauca-Bajaña Luis, Guim Martínez Carlos Andrés, et al. · Journal of clinical medicine · 2026 · PubMed · doi:10.3390/jcm15083161
Findings
10 findings
| Population | ||||
|---|---|---|---|---|
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: leave-one-out, omitting Shin 2019 | OR 3.17 [1.75, 5.73] GRADE not reported 4 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: leave-one-out, omitting Moergel 2013 | OR 3.76 [1.83, 7.71] GRADE not reported 4 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: leave-one-out, omitting Laprise 2016 | OR 3.86 [2.20, 6.79] GRADE not reported 4 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: Hartung-Knapp adjustment | OR 3.18 [1.50, 6.72] GRADE not reported 5 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: leave-one-out, omitting Tezal 2007 | OR 2.66 [1.63, 4.33] GRADE not reported 4 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based | OR 3.17 [1.94, 5.21] Low Downgraded: risk of bias, inconsistency 5 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: leave-one-out, omitting Moraes 2016 | OR 2.83 [1.80, 4.43] GRADE not reported 4 studies |
| Adults without prior oral cancer | Periodontal disease (clinical or radiographic criteria) | No periodontal disease or periodontal health | Risk of oral squamous cell carcinoma Population-based and hospital-based · Sensitivity: leave-one-out, all studies (random effects model) Unresolved: the two extractors disagree on this row. | OR 3.18 [1.94, 5.20] GRADE not reported 5 studies |
| Adults with oral squamous cell carcinoma | High intratumoral Porphyromonas gingivalis expression | Low or weak intratumoral P. gingivalis expression | Overall survival OSCC patients, immunohistochemistry on tumor tissue | HR 2.15 [1.33, 3.47] Very low Downgraded: risk of bias, imprecision 2 studies |
| Adults with oral squamous cell carcinoma | High intratumoral Porphyromonas gingivalis expression | Low or weak intratumoral P. gingivalis expression | Overall survival OSCC patients, immunohistochemistry on tumor tissue · Sensitivity: common (fixed) effect model | HR 2.15 [1.33, 3.47] GRADE not reported 2 studies |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Moergel 2013 Chronic periodontitis and its possible association with oral squamous cell carcinoma - a retrospective case control study. PMID:24321243 | 2013 | 2 other reviews | Risk of oral squamous cell carcinoma | not extracted yet |
| Guo 2021 Bioinformatics and immunohistochemistry analyses of expression levels and clinical significance of CXCL2 and TANs in an oral squamous cell… PMID:33574928 | 2021 | 1 other review | Overall survival | not extracted yet |
| Laprise 2016 Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. PMID:27215979 | 2016 | 1 other review | Risk of oral squamous cell carcinoma | not extracted yet |
| Li 2024 Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral… PMID:38671413 | 2024 | 1 other review | Overall survival | not extracted yet |
| Shin 2019 Association of Periodontitis with Oral Cancer: A Case-Control Study. PMID:30779879 | 2019 | 1 other review | Risk of oral squamous cell carcinoma | not extracted yet |
| Tezal 2007 Chronic periodontitis and the risk of tongue cancer. PMID:17515503 | 2007 | 1 other review | Risk of oral squamous cell carcinoma | not extracted yet |
| Moraes 2016 Association between Chronic Periodontitis and Oral/Oropharyngeal Cancer. PMID:27224557 | 2016 | this review only | Risk of oral squamous cell carcinoma | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults >=18 years without oral cancer (risk analysis); adults with OSCC (prognostic analysis) | Adults in 5 case-control studies (n=5); patients with OSCC in 2 retrospective cohorts (n=2) |
| Intervention | Periodontal disease (clinical or radiographic criteria); periodontal pathogens, particularly Porphyromonas gingivalis | Radiographic alveolar bone loss, gingival recession, chronic periodontitis (n=5); high intratumoral P. gingivalis expression by IHC (n=2) |
| Comparison | No periodontal disease or periodontal health; no detection of periodontal pathogens | Controls without periodontal disease (n=5); low P. gingivalis expression (n=2) |
| Outcomes | Risk of OSCC; overall survival, disease-free survival, cancer-specific survival | OSCC risk (n=5); overall survival (n=2) |
| Study designs | Case-control, cohort and population-based observational studies | Case-control (n=5); retrospective cohort (n=2) |
| Timing | Not specified | Not specified |