Primary study · included by 2 reviews

Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study.

Laprise 2016 · Laprise Claudie, Shahul Hameed Puthiyannal, Madathil Sreenath Arekunnath, et al. · International journal of cancer · 2016

Included by

Periodontitis and Oral and Oropharyngeal Cancer Risk: A Systematic Review and Meta-Analysis with Exploratory Evidence on Tumor-Associated Porphyromonas gingivalis.

Non-Cochrane · aetiology · 2026 · cited as Laprise 2016 · Table 1; Table 2; Reference list

Outcome this study informs	Pooled effect	Evidence	Certainty
Risk, incidence or mortality of oral and/or oropharyngeal cancer Clinically defined periodontitis (exposure) vs No periodontitis or periodontally healthy	Pooled risk estimates ranged approximately from RR about 1.9 to 2.6 after sequential exclusion of each study, remaining above unity	5 studies	GRADE not reported
Risk, incidence or mortality of oral and/or oropharyngeal cancer Clinically defined periodontitis (exposure) vs No periodontitis or periodontally healthy	HR 2.14 [1.53, 2.98]	6 studies	GRADE not reported

Periodontal Disease and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Risk and Survival Outcomes.

Non-Cochrane · prognostic · 2026 · cited as Laprise 2016 · Tables 1 and 2; reference list

Outcome this study informs	Pooled effect	Evidence	Certainty
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 2.66 [1.63, 4.33]	4 studies	GRADE not reported
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 3.17 [1.75, 5.73]	4 studies	GRADE not reported
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 3.86 [2.20, 6.79]	4 studies	GRADE not reported
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 3.76 [1.83, 7.71]	4 studies	GRADE not reported
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 3.17 [1.94, 5.21]	5 studies	Low
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 2.83 [1.80, 4.43]	4 studies	GRADE not reported
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 3.18 [1.50, 6.72]	5 studies	GRADE not reported
Risk of oral squamous cell carcinoma Periodontal disease (clinical or radiographic criteria) vs No periodontal disease or periodontal health	OR 3.18 [1.94, 5.20]	5 studies	GRADE not reported

2 including reviews in total.