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What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

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No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Intervention not reported

Pain VAS 0‐100 (higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Intervention not reported

Function WOMAC 0‐4 (Function; higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Intervention not reported

Function WOMAC 0‐4 (Overall; higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related infectious complication ‐ Subgroup Analysis for the effect of BMI on catheter colonization ‐ Highest BMI tercile (>28.4) · critically ill patients who were expected to require support with renal replacement therapy

Femoral probably leads to higher catheter‐related infectious complication ‐ Subgroup Analysis for the… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder

Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty).

1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Mortality: secondary to bleeding · People with a haematological disorder

Prophylactic platelet transfusion with one dose schedule showed no clear difference in mortality: secondary to bleeding ‐ High dosage platelet transfusions… compared with prophylactic platelet transfusions with another dose schedule (moderate certainty).

1 finding from 1 review

Single layer gastrointestinal anastomosis vs Double layer gastrointestinal anastomosis

Anastomotic leak in high quality trials Odds ratio · patients with Bowel resection

Single layer gastrointestinal anastomosis showed no clear difference in anastomotic leak in high quality trials Odds ratio compared with double layer gastrointestinal anastomosis (moderate certainty).

1 finding from 1 review

Intervention not reported

Cognitive function: 3. Short‐term ‐ Average end point score on various subscales of WAIS III (high = favourable) ‐ Digit symbol score · schizophrenia
1 finding from 1 review

Intervention not reported

Cognitive function: 4. Short‐term ‐ Average end point score on various subscales of HVLT (high = favourable) ‐ Recognition · schizophrenia
1 finding from 1 review

Intervention not reported

Vespid Quality of Life Questionnaire ‐ end of treatment Scale from 0 to 7, where a higher score indicates less quality of life impairment. · adults and children with a previous allergic reaction to an insect sting
1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (high endemicity) low risk of bias Dienstag 1999 · patients with preventing hepatitis A.

The intervention leads to lower clinically apparent hepatitis A (high endemicity) low risk of bias… (high certainty).

1 finding from 1 review

Intervention not reported

Clinically apparent hepatitis A (high endemicity) all included trials Dienstag 1999 · patients with preventing hepatitis A.

It is very uncertain whether the intervention changes clinically apparent hepatitis A (high endemicity) all included… (very low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Dropout ‐ Dropouts: excluding studies with high risk of bias objective · patients with cocaine abuse and dependence

Antidepressants showed no clear difference in dropout ‐ Dropouts: excluding studies with high risk of bias objective compared with placebo according to any definition (moderate certainty).

1 finding from 1 review