Cochrane · systematic review · CD004269
Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation
Estcourt, L, Stanworth, S, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
17
current version
GRADE rated
15
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 11.8%Very low 3 · 17.6%Low 5 · 29.4%Moderate 5 · 29.4%High 2 · 11.8%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prophylactic platelet transfusion compared to non prophylactic or therapeutic platelet transfusion for prevention of haemorrhage after chemotherapy and stem cell transplantation
Population: Patients with a haematological disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bleeding: Numbers of patients with at least one significant bleeding event Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion | RR 1.66 [0.9, 3.04] | 1 study · 56 participants | Low |
Bleeding: Number of days on which a significant bleeding event occurred3 Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion | RR 0.9 [0.62, 1.32] | 1 study · 342123 participants | Low Downgraded: imprecision |
Mortality: Secondary to bleeding Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion | RR 1.08 [0.23, 5.06] | 2 studies · 85 participants | Low Downgraded: imprecision, inconsistency |
Number of platelet transfusions Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion | no estimate extracted | 2 studies · 85 participants | Moderate |
Prophylactic platelet transfusion at threshold of 10,000 compared to higher transfusion threshold (20,000 or 30,000) for patients with a haematological disorder
Population: Patients with a haematological disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bleeding: Numbers of patients with at least one significant bleeding event Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | RR 1.35 [0.95, 1.9] | 3 studies · 499 participants | Moderate |
Bleeding: Number of days on which clinically significant bleeding occurred5 Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | RR 1.72 [1.33, 2.22] | 2 studies · 94205 participants | Moderate |
Mortality: secondary to bleeding Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | RR 2.67 [0.11, 64.91] | 3 studies · 499 participants | Low Downgraded: imprecision |
Number of platelet transfusions per patient Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | no estimate extracted | 2 studies · 333 participants | Moderate |
Prophylactic platelet transfusion with one dose schedule compared to prophylactic platelet transfusions with another dose schedule for patients with a haematological disorder
Population: Patients with a haematological disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Bleeding: Number of participants with a significant bleeding event ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule | RR 1.04 [0.95, 1.13] | 3 studies · 1070 participants | High |
Bleeding Number of participants with a significant bleeding event ‐ High dosage platelet transfusions versus standard dosage platelet transfusions Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule | RR 1.02 [0.93, 1.11] | 2 studies · 951 participants | High |
Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule | no estimate extracted | 3 studies · 3 participants | Ungraded |
Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule | no estimate extracted | 0 studies · 2 participants | Ungraded |
Mortality:secondary to bleeding ‐ Low dosage platelet transfusions versus standard dose platelet transfusions Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule | no estimate extracted | 3 studies · 859 participants | Low |
Mortality: secondary to bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule | RR 1.47 [0.06, 35.9] | 2 studies · 739 participants | Moderate |
Prophylactic platelet transfusion compared to platelet‐poor plasma for patients with a haematological disorder
Population: Patients with a haematological disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with a significant bleeding event Prophylactic platelet transfusion vs platelet‐poor plasma | RR 0.47 [0.23, 0.95] | 1 study · 21 participants | Very low |
Mortality: secondary to bleeding Prophylactic platelet transfusion vs platelet‐poor plasma | RR 2.31 [0.1, 50.85] | 1 study · 21 participants | Very low |
Number of platelet transfusions Prophylactic platelet transfusion vs platelet‐poor plasma | no estimate extracted | 0 studies · 1 participants | Very low |