Cochrane · systematic review · CD005504
Levodopa for the treatment of restless legs syndrome
Scholz, H, Trenkwalder, C, Kohnen, R, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Movement DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 7.1%Low 3 · 21.4%Moderate 10 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: levodopa versus placebo
Population: patients with restless legs syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Severity of symptoms (rating from 0 = not present to 10 = severe) Summary of findings: levodopa vs placebo | no estimate extracted | 2 studies · 48 participants | Moderate |
Periodic limb movements in sleep index (PLMSI) PLMS per hour of sleep (4 trials) or time in bed (1 trial) Summary of findings: levodopa vs placebo | no estimate extracted | 5 studies · 91 participants | Moderate |
Total sleep time (TST) Summary of findings: levodopa vs placebo | no estimate extracted | 4 studies · 59 participants | Low |
Dropouts due to adverse events Summary of findings: levodopa vs placebo | OR 0.73 [0.05, 11.34] | 6 studies · 109 participants | Moderate |
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse Summary of findings: levodopa vs placebo | no estimate extracted | 2 studies · 60 participants | Moderate |
Self rated quality of sleep SMD on SF‐A scale quality of sleep and VAS (0 to 10 = very good night) Summary of findings: levodopa vs placebo | no estimate extracted | 2 studies · 60 participants | Moderate |
Quality of life VAS on life satisfaction (0 to 50 = high) Summary of findings: levodopa vs placebo | no estimate extracted | 2 studies · 60 participants | Moderate |
Summary of findings: levodopa versus other dopamine agonists
Population: patients with restless legs syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IRLS Summary of findings: levodopa vs other dopamine agonists | no estimate extracted | 2 studies · 383 participants | Moderate |
Periodic limb movements per hour of time in bed (PLMI) Summary of findings: levodopa vs other dopamine agonists | no estimate extracted | 1 study · 39 participants | Low |
Total sleep time (TST) Summary of findings: levodopa vs other dopamine agonists | no estimate extracted | 1 study · 11 participants | Very low |
Number of drop outs due to adverse events Summary of findings: levodopa vs other dopamine agonists | OR 0.59 | 3 studies · 504 participants | Moderate |
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse Summary of findings: levodopa vs other dopamine agonists | no estimate extracted | 1 study · 344 participants | Moderate |
Self rated quality of sleep RLS‐6; scale satisfaction with sleep: 0 to 10 (= low satisfaction) Summary of findings: levodopa vs other dopamine agonists | no estimate extracted | 1 study · 344 participants | Low |
Quality of life RLS‐QoL: 0 to 60 (= severe impairment) Summary of findings: levodopa vs other dopamine agonists | no estimate extracted | 1 study · 314 participants | Moderate |