Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish did not differ significantly from P11-4 alone (SMD -0.40, 95% CI -0.97 to 0.17; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
White spot lesion clinical score (mean values), subject level · Healthy adolescents and adults undergoing orthodontic treatment with fixed multi-bracket appliances
In a pooled analysis of two placebo-controlled trials, fluoride varnish also reduced white spot lesion clinical scores (pooled SMD -0.44, 95% CI -0.64 to -0.24); this secondary outcome was not separately GRADE-rated.
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, amalgam had a higher risk of secondary caries than GIC (RR 1.79, 95% CI 1.04-3.09; low certainty).
1 finding from 1 review
Orthodontically-induced inflammatory root resorption (OIIRR) during molar intrusion · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
1 finding from 1 review
Not applicable (no eligible studies) · Adults with coronal (crown) dental caries in permanent teeth
No eligible studies assessed SDF for coronal caries in adults; this is an evidence gap identified by the review.
1 finding from 1 review
MMP-20 expression · Human carious dentin from irradiated and non-irradiated subjects
No difference in MMP-20 expression was found between irradiated and non-irradiated carious dentin (very low certainty).
1 finding from 1 review
Cariogenic bacteria (Mutans streptococci) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Probiotic mouthwash has inconsistent effects on Mutans streptococci colony counts versus blank control; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Treating traumatic dental injuries reduces their negative impact on OHRQoL in adolescents (narrative synthesis; included review reports low certainty; no pooled estimate or GRADE rating by the umbrella review).
1 finding from 1 review
Salivary flow rate (unstimulated) · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
codex
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Indians
Results were inconsistent and certainty was very low.
1 finding from 1 review
Orthodontic tooth movement (OTM) during alignment stage · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in orthodontic tooth movement (OTM) during alignment stage (reduction… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with ceramic restorations was 5.59%.
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with radiographic assessment was 4.95%.
2 findings from 1 review
Proportion 4.95 [2.43, 8.29]
5 studies · 1853 participants
GRADE not reported
Proportion 5.66 [3.71, 7.99]
24 studies · 6581 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Fluoride varnish (gold standard) did not differ significantly from control (SMD -0.25, 95% CI -0.51 to 0.02); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported no negative oral health-related quality-of-life impact from uncomplicated traumatic dental injuries.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Periapical pathosis incidence · Vital teeth
The pooled incidence with > 5–10 years of follow-up was 3.88%.
1 finding from 1 review
Harms: non-serious adverse effects (headache, discomfort, loosening of temporary anchorage devices) · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in harms: non-serious adverse effects (headache, discomfort, loosening… compared with conventional orthodontic appliance treatment (placebo or no adjunct); GRADE not reported.
1 finding from 1 review
Gingival index (GI) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash probably reduces the Gingival Index versus placebo in the short term (WMD -0.45, 95% CI -0.70 to -0.20; low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian elderly
Evidence on functional edentulism and OHRQoL is inconsistent across two studies (very low certainty).
2 findings from 1 review
Functional edentulism vs none: studies show inconsistency; one study found a significant association (Pushpanjali 2013), one did not (Shivakumar 2018); 368 participants, 2 observational studies; Very low certainty (Fig…
2 studies · 368 participants
Very low
SMD 0.31 [-0.37, 0.99]
4 studies · 1146 participants
Very low
Barriers and facilitators to implementation of the integration strategy (qualitative) · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…
Key barriers to implementing integration strategies were time/staff/resource constraints and lack of organisational support, while facilitators were professionals' knowledge and attitudes and supportive governance/leadership (qualitative; ungraded).
1 finding from 1 review