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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

10,375 questions in 429 reviews · Oral Health

current versions
No studies 1,344 · 13%Ungraded 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
In-office laser therapy (all types combined) vs Placebo (placebo laser or placebo agent) or no treatment
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Medium term (24 hours to 2 months)
Laser therapy for dentinal hypersensitivity (2021) · Cochrane
MD -2.46 [-3.57, -1.35]11 studies · 1007 participantsVery low
Four-point expansion appliance (Hyrax) vs Two-point expansion appliance
Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · 3 months after completion of expansion
Orthodontic treatment for posterior crossbites (2021) · Cochrane
Lamparski 2003: not reported by group; 'no significant differences were found'1 studyUngraded
Transillumination and optical coherence tomography devices (all illumination devices combined: NIR, OCT, and FOTI/DIFOTI) vs Reference standard: histology, or enhanced visual examination with or without radiographs (also operative excavation, tooth separation, or microcomputed tomography)
Specificity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)
Transillumination and optical coherence tomography for the detection and diagnosis of enamel caries (2021) · Cochrane
Specificity 0.87 [0.82, 0.92]23 studiesLow
Fixed tooth-borne expansion (quad-helix) vs Observation (no treatment)
Molar expansion (inter-molar distance) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children (7 to 11 years)
Orthodontic treatment for posterior crossbites (2021) · Cochrane
MD 4.71 [4.31, 5.10]3 studies · 146 participantsModerate
Diode laser, visible red (630 nm to 700 nm) vs Placebo (placebo laser or placebo agent) or no treatment
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Medium term (24 hours to 2 months)
Laser therapy for dentinal hypersensitivity (2021) · Cochrane
MD -2.95 [-5.14, -0.75]4 studiesUngraded
Caries severity measurement (mean dmft for primary dentition; mean DMFT for permanent dentition) vs None (descriptive prevalence review)
Caries severity/experience (mean dmft and DMFT) · Healthy children and adolescents (primary and permanent dentition) in the United Arab Emirates · UAE (multiple emirates); nurseries, schools and clinics
Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021)
Mean dmft (primary dentition) ranged from 0.75 (non-Emirati preschoolers, Abu Dhabi) to 10.9 (children at a pediatric dentistry department in Al Ain); among Emiratis mean dmft ranged 3.07-10.9. Mean DMFT (permanent…NRUngraded
Laser fluorescence (DIAGNOdent 2095) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
Sensitivity 0.75 [0.58, 0.86]6 studiesUngraded
Schwarz appliance vs No active treatment (control)
Amount of crowding (lower arch crowding, change) at 9 months · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · 9 months (after 6 months treatment)
Orthodontic treatment for crowded teeth in children (2021) · Cochrane
MD -2.14 [-2.79, -1.49]1 study · 28 participantsVery low
Diode laser, near infrared (700 nm to 850 nm) vs Placebo (placebo laser or placebo agent) or no treatment
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Medium term (24 hours to 2 months)
Laser therapy for dentinal hypersensitivity (2021) · Cochrane
MD -3.22 [-4.88, -1.56]4 studiesUngraded
Fixed tooth-borne expansion (Hyrax) vs Fixed tooth-tissue-borne expansion (Haas)
Molar expansion (inter-molar distance) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children
Orthodontic treatment for posterior crossbites (2021) · Cochrane
MD -0.15 [-0.86, 0.56]2 studies · 46 participantsModerate
Observed population vs Not applicable
Dental erosion prevalence · Five-year-old preschool children in Sharjah · Overall
Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021)
Prevalence 58.81 study · 403 participantsUngraded
Laser fluorescence pen (DIAGNOdent 2190/Pen) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
Sensitivity 0.63 [0.37, 0.83]4 studiesUngraded
Conventional bitewing radiography (E-speed film) vs Cavity preparation or biopsy (operative validation)
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces · in vivo
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
Sensitivity 0.80 [0.71, 0.87]1 studyUngraded
Visual or visual-tactile classification systems (any system: ICDAS, ERK, Nyvad, Downer, Lussi, UniViSS, or unspecified) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)
Diagnostic accuracy (sensitivity/specificity) for enamel caries, not meta-analyzed · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Smooth surface
Visual or visual‐tactile examination to detect and inform the diagnosis of enamel caries (2021) · Cochrane
Smooth surfaces reported by 2 datasets (Nakagawa 2013; Shi 2000) but excluded from the surface meta-analysis owing to sparsity; no summary sensitivity or specificity estimated.2 studiesUngraded
Glass ionomer cement vs Amalgam
Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible;… · 1 year
Materials for retrograde filling in root canal therapy (2021) · Cochrane
RR 0.98 [0.86, 1.12]1 studyVery low
Visual examination (VE) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
DOR 16.6 [4.85, 56.79]2 studiesUngraded
Fibre-optic transillumination (FOTI) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
DOR 37.77 [13.69, 104.19]2 studiesUngraded
Cone beam computed tomography (CBCT) vs Reference standard (histology, excavation, or enhanced visual examination)
Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies)
Imaging modalities to inform the detection and diagnosis of early caries (2021) · Cochrane
Sensitivity 0.60 [0.51, 0.68]7 studiesUngraded
Digital bitewing radiography, phosphor plate (PSP) vs Histological validation of dental tissues (gold standard)
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level
Systematic review and meta-analysis of diagnostic studies of proximal surface caries. (2021)
AUC 0.922 studiesUngraded
Conventional bitewing radiography (E-speed film) vs Cavity preparation or biopsy (operative validation)
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces · in vivo
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
DOR 60.37 [3.31, 1100.70]1 studyUngraded
Observed population vs Not applicable
Mean dmft/DMFT · School children aged 15-17 years in Dubai schools · Overall
Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021)
MEAN 2.701 study · 2063 participantsUngraded
Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances
White spot lesions (WSLs), tooth level · Adults undergoing orthodontic treatment · 3 months, Adults
Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… (2021)
RR 0.72 [0.60, 0.86]1 studyUngraded
Digital bitewing radiography, sensor-based (CCD/CMOS) vs Histological validation of dental tissues (gold standard)
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level
Systematic review and meta-analysis of diagnostic studies of proximal surface caries. (2021)
Specificity 0.95 [0.93, 0.97]4 studiesUngraded
0-19 remaining teeth vs 20-32 remaining teeth
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Crude
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021)
HR 2.27 [1.50, 3.43]1 study · 4380 participantsUngraded
Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)
Time taken for the canine to erupt into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for… (2021) · Cochrane
no estimate extracted0 studiesNo studies
Fixed tooth-borne expansion (Hyrax) vs Observation (no treatment)
Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children and adolescents
Orthodontic treatment for posterior crossbites (2021) · Cochrane
OR 48.02 [21.58, 106.87]3 studies · 93 participantsModerate
Conventional bitewing radiography (F-speed film) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
Specificity 0.97 [0.71, 0.998]2 studiesUngraded
Electrical conductance devices (electronic caries monitor (ECM) and/or CarieScan Pro), used as an adjunct to clinical oral examination vs Reference standard: histology or enhanced visual examination (with or without radiographs)
Specificity (test accuracy for detecting enamel caries) · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies)
Electrical conductance for the detection of dental caries (2021) · Cochrane
SoF findings (HSROC; no summary operating point reported): 'ECM: specificity from 0.73 to 0.96 ... CarieScan Pro: specificity from 0 to 1.00'. Across all 7 studies (8 datasets), covering 719 tooth surfaces or sites (no…7 studiesVery low
Conventional bitewing radiography (D-speed film) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
Specificity 0.73 [0.53, 0.87]1 studyUngraded
Visual or visual-tactile classification systems (any system: ICDAS, ERK, Nyvad, Downer, Lussi, UniViSS, or unspecified) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)
Sensitivity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Approximal surface
Visual or visual‐tactile examination to detect and inform the diagnosis of enamel caries (2021) · Cochrane
Sensitivity 0.80 [0.60, 0.92]NRUngraded
Laser fluorescence (DIAGNOdent 2190/pen) vs Histological validation of dental tissues (gold standard)
Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level
Systematic review and meta-analysis of diagnostic studies of proximal surface caries. (2021)
Sensitivity 0.82 [0.58, 0.94]5 studiesUngraded
Fibre-optic transillumination (FOTI) / digital fibre-optic transillumination (DIFOTI) vs Reference standard: histology, or enhanced visual examination with or without radiographs (also operative excavation, tooth separation, or microcomputed tomography)
Specificity for detection of enamel/early caries · Children or adults presenting asymptomatically or suspected of having enamel caries (clinical/in vivo studies);… · Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)
Transillumination and optical coherence tomography for the detection and diagnosis of enamel caries (2021) · Cochrane
Specificity 0.92 [0.86, 0.96]8 studiesUngraded
Visual examination (VE) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
AUC 0.593 studiesUngraded
Laser fluorescence (DIAGNOdent 2190/pen) vs Histological validation of dental tissues (gold standard)
Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Caries detection level
Systematic review and meta-analysis of diagnostic studies of proximal surface caries. (2021)
Specificity 0.89 [0.76, 0.95]5 studiesUngraded
Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction
Incidence of successfully erupted PDC that were favourably positioned · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC) · 12 months
Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for… (2021) · Cochrane
RR 1.09 [0.08, 15.42]1 study · 23 participantsUngraded
Laser fluorescence pen (DIAGNOdent 2190/Pen) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
Sensitivity 0.78 [0.44, 0.94]2 studiesUngraded
Selective carious tissue removal (selective excavation, SE) vs Stepwise carious tissue removal (SW)
Efficiency, costs or cost-effectiveness · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · Permanent and primary dentition
Interventions for treating cavitated or dentine carious lesions (2021) · Cochrane
Cost-effectiveness reported narratively: SE found more cost-effective than SW in permanent (Labib 2019) and primary teeth (Elhennawy 2021); not GRADE-rated.2 studiesUngraded
Laser fluorescence pen (DIAGNOdent 2190/Pen) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)
Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro
Systematic review and meta-analysis of diagnostic methods for occlusal surface caries. (2021)
AUC 0.772 studiesUngraded
Banded Hyrax (tooth-borne) vs Bonded Hyrax (tooth/tissue-borne)
Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · 3 months after completion of expansion
Orthodontic treatment for posterior crossbites (2021) · Cochrane
Asanza 1997: banded 6 mm (min 4.3-max 7.2) vs bonded 5.9 mm (min 3.2-max 7.7); P=NS (no SD reported); no significant difference in tipping or symmetrical expansion1 studyUngraded
Other visual classification systems (unspecified or unique systems, e.g. Nyvad, Downer, Lussi, UniViSS) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)
Sensitivity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies)
Visual or visual‐tactile examination to detect and inform the diagnosis of enamel caries (2021) · Cochrane
Sensitivity 0.81 [0.65, 0.91]16 studiesUngraded
Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo
Dry socket · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1… · 1st to 7th day
Antibiotics to prevent complications following tooth extractions (2021) · Cochrane
RR 0.66 [0.45, 0.97]13 studies · 1882 participantsLow
Private day care vs Public day care
Dental caries prevalence · Preschool children in Sharjah day cares · Public day cares
Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021)
Prevalence 221 study · 435 participantsUngraded
Maternal smoking during pregnancy vs No maternal smoking during pregnancy
Childhood dental caries · Children in cross-sectional studies · Poland, United States, Sweden, Italy, and Japan, Sensitivity: excluded Iida et al. 2007
Correlation Between Maternal Smoking During Pregnancy and Dental Caries in Children: A Systematic Review and… (2021)
OR 1.57 [1.47, 1.67]5 studiesUngraded
Visual classification: ICDAS (International Caries Detection and Assessment System) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)
Sensitivity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies)
Visual or visual‐tactile examination to detect and inform the diagnosis of enamel caries (2021) · Cochrane
Sensitivity 0.88 [0.81, 0.92]36 studiesUngraded
Maternal smoking during pregnancy vs No maternal smoking during pregnancy
Childhood dental caries · Children in cross-sectional studies · Poland, United States, Sweden, Italy, and Japan, Sensitivity: excluded Tanaka et al. 2015
Correlation Between Maternal Smoking During Pregnancy and Dental Caries in Children: A Systematic Review and… (2021)
OR 1.57 [1.47, 1.67]5 studiesUngraded
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model)
Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Deciduous tooth decay
Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021)
OR 1.40 [0.91, 2.15]2 studies · 929 participantsUngraded
Resin infiltration (Icon) vs Non-invasive treatment
Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up, Caries risk: low
Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021)
OR 0.24 [0.08, 0.72]2 studiesUngraded
Down syndrome vs Healthy controls
Gingivitis prevalence · Children with Down syndrome in Dubai · Children with Down syndrome
Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021)
Prevalence 65.41 studyUngraded
Intervention NR
Dental caries prevalence · General population (children and adults) in East Africa · Community- and school-based populations, East Africa, Sudan
Prevalence of Dental Caries and Associated Factors in East Africa, 2000-2020: Systematic Review and… (2021)
Prevalence 0.578 [0.360, 0.797]NRUngraded
Diode laser, near infrared (850 nm to 980 nm) vs Placebo (placebo laser or placebo agent) or no treatment
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Short term (0 to 24 hours)
Laser therapy for dentinal hypersensitivity (2021) · Cochrane
MD -1.90 [-2.49, -1.31]1 studyUngraded