Search review questions

Pocket/probing depth (PD) · Adults undergoing orthodontic treatment · 6 to 12 weeks, Adults

Detection rate of oral pre-malignant and malignant lesions after referral (COE+vital rinsing vs COE alone) · OSCC or OPMD symptom-free individuals with tobacco habits

Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

White spot lesions (WSLs), patient level · Adolescents/teenagers undergoing orthodontic treatment · 9 months, Adolescents

Gingivitis / gingival health · Children and adolescents in the United Arab Emirates (Sharjah)

Dentist satisfaction (masking effect) · Patients with dental fluorosis

Dental caries (DMF-t/DMF-s and related caries indices) · Patients with IBD (Crohn's disease and ulcerative colitis) and controls without IBD

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Dentin detection level

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Dentin detection level

Overall survival, adjuvant chemotherapy vs observation alone following surgery · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Sensitivity analysis: excluding high/unclear risk of bias reference standard

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Reference standard: excavation (non-CBCT)

Tooth wear prevalence · School children (primary dentition) in the United Arab Emirates (Abu Dhabi)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

Mean plaque score · Children aged 5-6 years in Ajman schools · Overall

Water samples with fluoride concentration outside the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), CBCT

Significant caries index · Preschool children in Dubai · Overall

White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Dentine-caries (D3) prevalence medium 15-34% (non-CBCT)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies)

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Dentin detection level

Dental caries prevalence · School children aged 11-17 years in Sharjah · Overall

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies)

Incidence of new white spot lesions by visual-tactile assessment · Patients receiving comprehensive fixed orthodontic treatment · 1 to 24 months, Compomer-based bonding agents

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Ethnicity: Caucasian

Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa · Eritrea

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Dentin detection level

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · Cavitated but not deep lesions, primary dentition

S. mutans presence · Adolescents/teenagers undergoing orthodontic treatment · 1 month, Adolescents

Streptococcus mutans load in the oral cavity (saliva and/or dental plaque) · Adults and children (general population) · Final/end-of-study time point (follow-up 2 weeks to 18 months), Sensitivity analysis: baseline-to-endpoint correlation 0.95 for SFG arm

Difference in sensitivity · Children or adults asymptomatic or suspected of enamel caries; extracted teeth · Analysis 1: fully within-person comparison

Diagnostic accuracy on surfaces with pit and fissure sealants · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Pit and fissure sealants

Initiation of white spot lesions (WSL), visual-tactile assessment · Sensitivity (glass ionomer cement vs resin adhesive, excluding high risk-of-bias studies)

Dental caries (presence) · Individuals in Ethiopia assessed for dental caries

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · Dentin detection level

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Setting: in vivo / clinical (non-CBCT)

Clinical evaluation of restoration's quality · Dental patients undergoing restorative treatment (no age or gender restriction)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Analogue

Dental caries (presence) · Individuals in Ethiopia assessed for dental caries

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: low to moderate

Samples with fluoride concentration above the acceptable range · Brazilian cities in the Northeast region with artificially fluoridated public water supplies · 1995-2013, Northeast region

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · Dentin detection level

Water samples with fluoride concentration outside the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control) · Region: Southeast Brazil

Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Mean DMFT · Preterm children aged 5-10 years in Dubai · Preterm children

Dental caries · Healthy children and adolescents in the United Arab Emirates

Adverse events · Dental patients undergoing restorative treatment (no age or gender restriction) · treatment phase