Non-Cochrane · aetiology · PM34770034
Oral Health Status in Patients with Inflammatory Bowel Diseases: A Systematic Review.
Nijakowski Kacper, Gruszczyński Dawid, Surdacka Anna · International journal of environmental research and public health · 2021 · PubMed · doi:10.3390/ijerph182111521
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
4
current version
GRADE rated
0
No studies
0
Included studies
16
linked below
No studies 0 · 0%Ungraded 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with IBD (Crohn's disease and ulcerative colitis), aged 0-99 years, both sexes; excluding patients with another bowel or autoimmune disease | 1748 participants across 15 studies in 11 countries (1104 Crohn's disease, 534 ulcerative colitis, 110 IBD-form unspecified); one pediatric study |
| Intervention | Not applicable per protocol (observational; exposure = IBD diagnosis) | IBD (Crohn's disease and ulcerative colitis) as diagnosed |
| Comparison | Not applicable per protocol (healthy controls where a control group existed) | Healthy controls (11/15 studies had a control group; 4 studies had no control group) |
| Outcomes | Clinical indices evaluating oral hygiene, and dental and periodontal status; studies determining only presence of oral lesions excluded | Periodontal disease meta-analyzed (OR: IBD 2.49 [1.97-3.15], 6 studies; CD 2.10 [1.59-2.78], 5 studies; UC 3.25 [2.23-4.74], 5 studies; all p<0.0001). Dental caries (DMF-t/DMF-s) and oral hygiene/plaque and gingival indices reported narratively (Table 3), not pooled due to heterogeneity. |
| Study designs | Case-control, cohort and cross-sectional studies; published after 2000, in English | 15 observational studies (case-control, cohort, cross-sectional); 6 pooled in meta-analysis |
| Timing | Not specified (no follow-up/timing restriction) | Studies published 2003-2021 |
Search date: Up to 1 October 2021. Databases: PubMed, Scopus, Web of Science
Questions and results
Inflammatory bowel disease (IBD; Crohn's disease or ulcerative colitis) vs Healthy controls without IBD
Population: Patients with inflammatory bowel disease (IBD) and controls without IBD; mostly adults (one pediatric study), both sexes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Periodontal disease (periodontitis) coincidence Patients with IBD have about 2.5-fold higher odds of coexisting periodontal disease than healthy controls (pooled OR 2.49, 95% CI 1.97-3.15; 6 studies; not GRADE-rated). Source: Figure 3 (forest plot, Summary row); Abstract; Results para 1 · same question in other reviews | OR 2.49 [1.97, 3.15] | 6 studies | Ungraded |
Crohn's disease (CD) vs Healthy controls without IBD
Population: Patients with Crohn's disease (CD) and controls without IBD; adults, both sexes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Periodontal disease (periodontitis) coincidence Crohn's disease (CD) vs healthy controls Patients with Crohn's disease have about 2-fold higher odds of periodontal disease than controls (pooled OR 2.10, 95% CI 1.59-2.78; 5 studies; ungraded). Source: Figure 4 (forest plot, Summary row); Results para 1 · same question in other reviews | OR 2.10 [1.59, 2.78] | 5 studies | Ungraded |
Ulcerative colitis (UC) vs Healthy controls without IBD
Population: Patients with ulcerative colitis (UC) and controls without IBD; adults, both sexes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Periodontal disease (periodontitis) coincidence Ulcerative colitis (UC) vs healthy controls Patients with ulcerative colitis have about 3-fold higher odds of periodontal disease than controls (pooled OR 3.25, 95% CI 2.23-4.74; 5 studies; ungraded). Source: Figure 5 (forest plot, Summary row); Results para 1 · same question in other reviews | OR 3.25 [2.23, 4.74] | 5 studies | Ungraded |
Inflammatory bowel disease (IBD) vs Healthy controls without IBD
Population: Patients with IBD (Crohn's disease and ulcerative colitis) and controls without IBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries (DMF-t/DMF-s and related caries indices) Most included studies reported higher dental caries indices (DMF-t/DMF-s) in IBD patients (especially ulcerative colitis), but findings were inconsistent across studies and were not meta-analyzed or GRADE-rated. Source: Table 3; Abstract; Discussion; Conclusions · same question in other reviews | Not meta-analyzed (heterogeneity of caries indices). Abstract: "in most studies, patients with IBD were characterized by higher values of caries indices." Table 3 examples (IBD/subtype vs control): Zhang 2020 DMF-t… | NR | Ungraded |
Included primary studies 16
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Brito 2008 Prevalence of periodontitis and DMFT index in patients with Crohn's disease and ulcerative colitis DOI:10.1111/j.1600-051x.2008.01231.x | this review only | Periodontal disease (periodontitis) coincidence | not extracted yet | not extracted yet |
| Groselj 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Grošelj 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Grossner-Schreiber 2006 Prevalence of dental caries and periodontal disease in patients with inflammatory bowel disease: a case–control study DOI:10.1111/j.1600-051x.2006.00942.x | this review only | Periodontal disease (periodontitis) coincidence | not extracted yet | not extracted yet |
| Habashneh 2012 The association between inflammatory bowel disease and periodontitis among Jordanians: a case–control study DOI:10.1111/j.1600-0765.2011.01431.x | this review only | Periodontal disease (periodontitis) coincidence | not extracted yet | not extracted yet |
| Koutsochristou 2015 Dental Caries and Periodontal Disease in Children and Adolescents with Inflammatory Bowel Disease DOI:10.1097/mib.0000000000000452 | this review only | not stated | not extracted yet | not extracted yet |
| Menegat 2016 Cytokine expression in gingival and intestinal tissues of patients with periodontitis and inflammatory bowel disease: An exploratory study DOI:10.1016/j.archoralbio.2016.02.018 | this review only | not stated | not extracted yet | not extracted yet |
| Piras 2017 Prevalence of Apical Periodontitis in Patients with Inflammatory Bowel Diseases: A Retrospective Clinical Study DOI:10.1016/j.joen.2016.11.004 | this review only | not stated | not extracted yet | not extracted yet |
| Rodrigues 2019 ARE CARIOGENIC BACTERIA THE MAJOR RISK FACTOR TO DENTAL CARIES IN PATIENTS WITH ULCERATIVE COLITIS? DOI:10.1590/s0004-2803.201900000-25 | this review only | not stated | not extracted yet | not extracted yet |
| Schmidt 2018 Active matrix metalloproteinase‐8 and periodontal bacteria—interlink between periodontitis and inflammatory bowel disease? DOI:10.1002/jper.17-0486 | this review only | Periodontal disease (periodontitis) coincidence | not extracted yet | not extracted yet |
| Schutz 2003 Sugar Intake, Taste Changes and Dental Health in Crohn’s Disease DOI:10.1159/000073343 | this review only | not stated | not extracted yet | not extracted yet |
| Stein 2010 Clinical Periodontal and Microbiologic Parameters in Patients With Crohn's Disease With Consideration of the CARD15 Genotype DOI:10.1902/jop.2009.090563 | this review only | not stated | not extracted yet | not extracted yet |
| Szymanska 2014 Dental caries, prevalence and risk factors in patients with Crohn's disease. PMID:24608416 | this review only | not stated | not extracted yet | not extracted yet |
| Tan 2021 Dental and periodontal disease in patients with inflammatory bowel disease. PMID:33619633 | this review only | not stated | not extracted yet | not extracted yet |
| Vavricka 2013 Periodontitis and Gingivitis in Inflammatory Bowel Disease DOI:10.1097/01.mib.0000438356.84263.3b | this review only | Periodontal disease (periodontitis) coincidence | not extracted yet | not extracted yet |
| Zhang 2020 Increased risks of dental caries and periodontal disease in Chinese patients with inflammatory bowel disease. PMID:31998967 | this review only | Periodontal disease (periodontitis) coincidence | not extracted yet | not extracted yet |