Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

696 questions · 700 findings · 53 reviews · Anaesthesia

No studies found 107 · 15.3%GRADE not reported 151 · 21.6%Very low 144 · 20.6%Low 178 · 25.4%Moderate 97 · 13.9%High 23 · 3.3%

Supplemental IV crystalloid vs control IV crystalloid volume

Nausea · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

Supplemental IV crystalloid probably leads to lower risk of PON, defined as the presence of subjective nausea, reported… compared with control IV crystalloid volume (moderate certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes postextubation stridor (defined as any inspiratory sound or… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Intervention not reported

High‐intensity pain with lidocaine pretreatment Pain scales · Adult participants receiving propofol for induction of anaesthesia

The intervention leads to lower high‐intensity pain with lidocaine pretreatment Pain scales (high certainty).

1 finding from 1 review

Intervention not reported

Incidence of pain with lidocaine pretreatment Pain scales · Adult participants receiving propofol for induction of anaesthesia

The intervention leads to lower incidence of pain with lidocaine pretreatment Pain scales (high certainty).

1 finding from 1 review

Peribulbar vs retrobulbar

Local complications ‐ Conjunctival chemosis presence of conjunctival chemosis · patients undergoing cataract surgery

Peribulbar probably leads to higher local complications ‐ Conjunctival chemosis presence of conjunctival… compared with retrobulbar (moderate certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Parental presence vs. midazolam Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Parental presence vs. midazolam Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Block success (predicted adequacy of block) · People undergoing upper and lower limb blocks

The intervention probably leads to higher block success (predicted adequacy of block) (moderate certainty).

1 finding from 1 review

Regional anaesthesia vs conventional pain control

Knee Society Score compared to preoperative value · people undergoing total knee replacement
2 findings from 1 review

rHuEPO with iron vs control treatment with or without iron

Blood transfusion · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron probably leads to lower transfusion (measured in participants during or up to 5 days after… compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO high (500 to 600 IU/kg BW) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO low (150 to 300 IU/kg BW) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Number of RBC units transfused per participant (intraoperative to 5 days postoperative) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Mortality (within 30 days after surgery) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in mortality (within 30 days after surgery) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Adverse events (number of participants with any adverse event) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in adverse events (number of participants with any adverse event) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review