Cochrane · systematic review · CD012451
Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non‐cardiac surgery
Kaufner, L, von Heymann, C, Henkelmann, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
rHuEPO with iron compared to control treatment with or without iron in preoperative anaemic adults undergoing non‐cardiac surgery
Population: adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Transfusion (measured in participants during or up to 5 days after operation) rHuEPO with iron vs control treatment with or without iron | RR 0.55 [0.38, 0.8] | 12 studies · 1880 participants | Moderate Downgraded: inconsistency |
Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO high (500 to 600 IU/kg BW) rHuEPO with iron vs control treatment with or without iron | no estimate extracted | 3 studies · 852 participants | Low Downgraded: risk of bias, inconsistency |
Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO low (150 to 300 IU/kg BW) rHuEPO with iron vs control treatment with or without iron | no estimate extracted | 4 studies · 334 participants | Low Downgraded: risk of bias, inconsistency |
Number of RBC units transfused per participant (intraoperative to 5 days postoperative) rHuEPO with iron vs control treatment with or without iron | no estimate extracted | 6 studies · 1420 participants | Moderate Downgraded: imprecision |
Mortality (within 30 days after surgery) rHuEPO with iron vs control treatment with or without iron | RR 1.18 [0.39, 3.63] | 2 studies · 230 participants | Moderate Downgraded: imprecision |
Adverse events (number of participants with any adverse event) rHuEPO with iron vs control treatment with or without iron | RR 0.93 [0.68, 1.28] | 10 studies · 1722 participants | Moderate Downgraded: imprecision |
Length of hospital stay rHuEPO with iron vs control treatment with or without iron | no estimate extracted | 3 studies · 293 participants | Low Downgraded: imprecision, inconsistency |