Cochrane · systematic review · CD006581
Adjusting the pH of lidocaine for reducing pain on injection
Cepeda M Soledad, Tzortzopoulou Aikaterini, Thackrey Michael, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 33.3%High 2 · 66.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Plain lidocaine compared to buffered lidocaine for patients requiring local anaesthesia
Population: Patients requiring local anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain at injection site VAS. Scale from 0 to 10. Plain lidocaine vs buffered lidocaine | no estimate extracted | 7 studies · 685 participants | Moderate Downgraded: risk of bias, inconsistency |
Preference Plain lidocaine vs buffered lidocaine | OR 3.01 [1.19, 4.15] | 8 studies · 346 participants | High |
Adverse events Plain lidocaine vs buffered lidocaine | no estimate extracted | 3 studies · 182 participants | High |