Cochrane · systematic review · CD012212
Supplemental perioperative intravenous crystalloids for postoperative nausea and vomiting
Jewer, JK, Wong, MJ, Bird, SJ, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Supplemental IV crystalloid compared to control IV crystalloid volume for postoperative nausea and vomiting
Population: participants aged 6 months or older undergoing surgical procedures under general anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Risk of PON, defined as the presence of subjective nausea, reported dichotomously or based on a study‐defined dichotomous threshold on a continuous scale such as a VAS Supplemental IV crystalloid vs control IV crystalloid volume | RR 0.62 [0.51, 0.75] | 18 studies · 1766 participants | Moderate Downgraded: publication bias |
Risk of POV, reported dichotomously by any discrete episodes of vomiting Supplemental IV crystalloid vs control IV crystalloid volume | RR 0.5 [0.4, 0.63] | 20 studies · 1970 participants | Moderate Downgraded: publication bias |
Risk of requiring pharmacologic treatment for PONV, reported dichotomously as the use of any medication intended to treat nausea or vomiting during the postoperative period Supplemental IV crystalloid vs control IV crystalloid volume | RR 0.62 [0.51, 0.76] | 23 studies · 2416 participants | Moderate Downgraded: publication bias |
Risk of unintended postoperative admission to hospital, reported dichotomously as admission to an inpatient unit of a participant after an intended ambulatory surgical procedure Supplemental IV crystalloid vs control IV crystalloid volume | RR 1.05 [0.77, 1.43] | 3 studies · 235 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Risk of suffering a serious adverse event, reported dichotomously as the occurrence of any of: admission to high‐dependency unit, postoperative cardiac or respiratory complication, or death Supplemental IV crystalloid vs control IV crystalloid volume | no estimate extracted | NR | No studies |