Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,231 questions · 3,354 findings · 394 reviews

No studies found 803 · 23.9%GRADE not reported 267 · 8%Very low 757 · 22.6%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Inhaled NO vs control

Death or use of ECMO; studies that did not allow back‐up use of iNO in controls · respiratory failure in infants born at or near term

Inhaled NO leads to lower death or use of ECMO; studies that did not allow back‐up use of iNO… compared with control (high certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Minor bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to higher minor bleeding compared with aspirin alone (moderate certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Vitamin A deficiency · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of… compared with control (high certainty).

2 findings from 1 review

Intervention not reported

Entomological inoculation rate · people living in malaria‐endemic areas

The review found no eligible studies for this question.

1 finding from 1 review

Cerebral NIRS oximetry vs no cerebral NIRS oximetry

Retinopathy of prematurity, any or severe (stage ≥ III) · patients with preventing morbidity and mortality in very preterm infants

It is very uncertain whether cerebral NIRS oximetry changes retinopathy of prematurity, any or severe (stage ≥ III) compared with no cerebral NIRS oximetry (very low certainty).

1 finding from 1 review