Cochrane · systematic review · CD011190
Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants
Askie, LM, Darlow, BA, Davis, PG, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 33.3%High 4 · 66.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oxygen saturation targeting in preterm infants
Population: extremely preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or major disability by 18 to 24 months corrected age (aligned definition) | RR 1.04 [0.98, 1.1] | 5 studies · 4754 participants | High |
Death to 18 to 24 months corrected age | RR 1.16 [1.03, 1.31] | 5 studies · 4873 participants | High |
Major disability by 18 to 24 months corrected age (aligned definition) | RR 1.01 [0.93, 1.09] | 5 studies · 3867 participants | High |
Retinopathy of prematurity requiring treatment | RR 0.72 [0.61, 0.85] | 5 studies · 4089 participants | Moderate Downgraded: inconsistency |
Necrotising enterocolitis | RR 1.24 [1.05, 1.47] | 5 studies · 4929 participants | High |
Blindness | RR 1.13 [0.65, 1.97] | 5 studies · 3875 participants | Moderate Downgraded: imprecision, inconsistency |