Cochrane · systematic review · CD006652

Parenteral anticoagulation in ambulatory patients with cancer

Akl, EA, Kahale, LA, Hakoum, MB, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Gynaecological, Neuro-oncology and Orphan Cancer5 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 2 · 28.6%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Heparin prophylaxis compared with no prophylaxis in ambulatory patients with cancer without VTE receiving systemic therapy

7 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality Heparin prophylaxis vs no prophylaxis	RR 0.98 [0.93, 1.03]	18 studies · 9575 participants	Moderate Downgraded: imprecision
Mortality Heparin prophylaxis vs no prophylaxis	RR 0.99 [0.96, 1.01]	14 studies · 5229 participants	Moderate Downgraded: imprecision
Symptomatic VTE Heparin prophylaxis vs no prophylaxis	RR 0.56 [0.47, 0.68]	16 studies · 9036 participants	High
Major bleeding Heparin prophylaxis vs no prophylaxis	RR 1.3 [0.94, 1.79]	18 studies · 9592 participants	Moderate Downgraded: risk of bias, imprecision
Minor bleeding Heparin prophylaxis vs no prophylaxis	RR 1.7 [1.13, 2.55]	16 studies · 9245 participants	High
Thrombocytopenia Heparin prophylaxis vs no prophylaxis	RR 0.69 [0.37, 1.27]	12 studies · 5832 participants	Moderate Downgraded: risk of bias, imprecision
Quality of life impairment Heparin prophylaxis vs no prophylaxis	no estimate extracted	2 studies · 2241 participants	Moderate Downgraded: risk of bias, imprecision