Cochrane · systematic review · CD011343
Pharmacological interventions for primary sclerosing cholangitis
Saffioti, F, Gurusamy, KS, Hawkins, N, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
5
No studies
5
Included studies
NR
No studies 5 · 50%Ungraded 0 · 0%Very low 5 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ursodeoxycholic acid versus placebo for primary sclerosing cholangitis
Population: people with primary sclerosing cholangitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Ursodeoxycholic acid vs placebo | OR 1.51 [0.63, 3.63] | 2 studies · 348 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Ursodeoxycholic acid vs placebo | no estimate extracted | NR | No studies |
Proportion of people with adverse events Ursodeoxycholic acid vs placebo | OR 1.22 [0.68, 2.17] | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
Number of adverse events Ursodeoxycholic acid vs placebo | no estimate extracted | NR | No studies |
Health‐related quality of life Ursodeoxycholic acid vs placebo | no estimate extracted | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
Liver transplantation Ursodeoxycholic acid vs placebo | OR 0.97 [0.52, 1.81] | 2 studies · 348 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Any malignancy Ursodeoxycholic acid vs placebo | no estimate extracted | NR | No studies |
Cholangiocarcinoma Ursodeoxycholic acid vs placebo | OR 1.34 [0.48, 3.68] | 2 studies · 348 participants | Very low Downgraded: risk of bias, imprecision |
Colorectal cancer Ursodeoxycholic acid vs placebo | no estimate extracted | NR | No studies |
Cholecystectomy Ursodeoxycholic acid vs placebo | no estimate extracted | NR | No studies |