Cochrane · systematic review · CD005158
Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events
Squizzato, A, Bellesini, M, Takeda, A, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
clopidogrel plus aspirin compared to aspirin alone for preventing cardiovascular events
Population: people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cardiovascular mortality clopidogrel plus aspirin vs aspirin alone | RR 0.98 [0.88, 1.1] | 7 studies · 31903 participants | Moderate Downgraded: publication bias |
All‐cause mortality clopidogrel plus aspirin vs aspirin alone | RR 1.05 [0.87, 1.25] | 9 studies · 32908 participants | Low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Fatal and non‐fatal myocardial infarction clopidogrel plus aspirin vs aspirin alone | RR 0.78 [0.69, 0.9] | 6 studies · 16175 participants | Moderate Downgraded: publication bias |
Fatal and non‐fatal ischaemic stroke clopidogrel plus aspirin vs aspirin alone | RR 0.73 [0.59, 0.91] | 5 studies · 4006 participants | Moderate Downgraded: risk of bias, imprecision, indirectness, publication bias |
Adverse events clopidogrel plus aspirin vs aspirin alone | no estimate extracted | 1 study · 181 participants | Very low Downgraded: publication bias |
Major bleeding clopidogrel plus aspirin vs aspirin alone | RR 1.44 [1.25, 1.64] | 10 studies · 33300 participants | Moderate Downgraded: risk of bias, imprecision, indirectness, publication bias |
Minor bleeding clopidogrel plus aspirin vs aspirin alone | RR 2.03 [1.75, 2.36] | 8 studies · 14731 participants | Moderate Downgraded: risk of bias, imprecision, indirectness, publication bias |