Cochrane · systematic review · CD011373
Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation patients with chronic kidney disease
Kimachi, M, Furukawa, TA, Kimachi, K, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 2 · 28.6%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Direct oral anticoagulants (DOAC) versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation patients with chronic kidney disease (CKD)
Population: atrial fibrillation patients with CKD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All strokes and systemic embolic events Direct oral anticoagulants (DOAC) vs warfarin | RR 0.81 [0.65, 1] | 5 studies · 12545 participants | Moderate Downgraded: imprecision, inconsistency |
Major bleeding Direct oral anticoagulants (DOAC) vs warfarin | RR 0.79 [0.59, 1.04] | 5 studies · 12521 participants | Low Downgraded: imprecision, inconsistency |
Myocardial infarction Direct oral anticoagulants (DOAC) vs warfarin | RR 0.92 [0.45, 1.9] | 1 study · 2740 participants | Ungraded |
Minor bleeding Direct oral anticoagulants (DOAC) vs warfarin | RR 0.97 [0.58, 1.61] | 2 studies · 3012 participants | Low Downgraded: imprecision, inconsistency |
Gastrointestinal bleeding Direct oral anticoagulants (DOAC) vs warfarin | RR 1.4 [0.97, 2.01] | 2 studies · 5678 participants | Moderate Downgraded: imprecision, inconsistency |
Intracranial haemorrhage Direct oral anticoagulants (DOAC) vs warfarin | RR 0.43 [0.27, 0.69] | 5 studies · 12521 participants | Moderate Downgraded: imprecision, inconsistency |
All‐cause mortality Direct oral anticoagulants (DOAC) vs warfarin | RR 0.91 [0.78, 1.05] | 4 studies · 9595 participants | Moderate Downgraded: imprecision, inconsistency |