Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Specificity for dental caries diagnosis · Children and adults with primary or permanent dentition
Specificity ranged from 83% to 100% across 13 studies; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
13 studies
GRADE not reported
Dental caries · Children (<18 years) with vs without dental caries
Over-dominant model (CC+TT vs CT) at FokI(rs10735810) showed no significant association with caries (OR 0.83); ungraded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
FokI(rs2228570) allelic model: A vs G was not significantly associated with dental caries (OR 1.07); ungraded.
1 finding from 1 review
Enamel acid resistance (cross-sectional microhardness) · Human enamel in pits and fissures (in situ / ex vivo)
Nd:YAG laser increased enamel acid resistance versus untreated enamel in pits and fissures (ungraded, 1 ex-vivo study, no pooled estimate).
1 finding from 1 review
Dental caries in children · Children aged 4 to 6 years whose mothers' prenatal vitamin D status was assessed
Among children aged 4-6 years, prenatal vitamin D deficiency is associated with significantly higher odds of dental caries (OR 1.44, 95% CI 1.32-1.56); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPrenatal exposure; dental caries at 4 to 6 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 4 to 6 years
OR 1.44 [1.32, 1.56]
8 studies
GRADE not reported
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF and ART/glass ionomer cement showed no clear difference in tooth-level caries arrestment (OR 1.22, wide CI; ungraded subgroup).
1 finding from 1 review
Calcium ions released in acidic solution · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation did not significantly change calcium ions released into acidic solution versus untreated control (SMD -0.40, 95% CI -0.96 to 0.15; 6 in vitro studies, I2=80%; ungraded).
1 finding from 1 review
Pulp necrosis · Vital teeth restored with indirect restorations
Pulp necrosis incidence among treated by prosthodontists was 1.87% (subgroup analysis; not GRADE-rated).
23 findings from 1 review
Show 20 more findings
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Temporization >2 weeks
Proportion 4.25 [1.28, 8.85]
2280 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomes>10 years · University clinics and dental practices, multiple countries · Follow-up >10 years
Proportion 6.74 [2.82, 12.18]
3640 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Temporization ≤2 weeks
Proportion 1.47 [0.81, 2.31]
1907 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Radiographic pulp-status assessment
Proportion 4.95 [2.43, 8.29]
1853 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Polyvinyl siloxane impression material
Proportion 3.17 [1.55, 5.34]
636 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Resin permanent cement
Proportion 3.37 [1.90, 5.23]
738 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Eugenol-based temporary cement
Proportion 3.34 [1.66, 5.58]
7043 participants
GRADE not reported
Proportion 3.53 [2.10, 5.31]
5532 participants
GRADE not reported
Proportion 5.02 [3.70, 6.52]
37 studies · 11615 participants
Low
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Treated by general practitioners
Proportion 4.44 [2.16, 7.49]
2113 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Single-unit restorations
Proportion 5.46 [3.63, 7.64]
20 studies · 5491 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Zinc phosphate permanent cement
Proportion 4.92 [3.85, 6.20]
1387 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Polyether impression material
Proportion 4.02 [2.47, 5.92]
2985 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Ceramic fabrication material
Proportion 5.59 [2.89, 9.12]
460 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Subjective pulp-status assessment
Proportion 3.91 [1.86, 6.66]
3181 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Eugenol-free temporary cement
Proportion 5.77 [3.72, 8.24]
639 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Treated by undergraduate students
Proportion 5.68 [3.17, 8.86]
1604 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Glass ionomer (GIC) permanent cement
Proportion 5.33 [2.56, 9.03]
182 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Objective pulp-status assessment
Proportion 5.66 [3.71, 7.99]
6581 participants
GRADE not reported
Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations: a… 2023 All outcomesFollow-up ≤5 to >10 years · University clinics and dental practices, multiple countries · Fixed partial dentures (FPD)
Proportion 5.01 [2.76, 7.88]
15 studies · 4674 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration did not differ significantly from CPP-ACFP (SMD -0.52, 95% CI -1.16 to 0.12; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Preschool children with mutans streptococci at baseline probably have about four times higher odds of developing early childhood caries (OR 4.13; moderate certainty).
10 findings from 1 review
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Overall
OR 4.13 [3.33, 5.12]
12 studies · 3010 participants
Moderate
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Sample: plaque
OR 5.16 [2.99, 8.91]
5 studies · 736 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Sample: saliva
OR 3.92 [3.20, 4.80]
9 studies · 2577 participants
GRADE not reported
Show 7 more findings
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes1 year · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 1 year
OR 4.37 [3.50, 5.45]
4 studies · 2016 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes2.7 years (31 months median) · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 2.7 years (31 months median)
OR 33.00 [3.18, 342.26]
1 study · 28 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes2 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 2 years
OR 2.53 [1.22, 5.23]
4 studies · 297 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Microbiological assessment: quantitative (culture/CFU counting)
OR 3.82 [2.01, 7.26]
6 studies · 732 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes3.5 years (42 months) · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 3.5 years (42 months)
OR 4.23 [2.49, 7.18]
1 study · 366 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Follow-up: 6 months
OR 4.65 [2.01, 10.76]
2 studies · 303 participants
GRADE not reported
Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes6 months to 3.5 years · Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore · Microbiological assessment: semi-quantitative (Dentocult/commercial kit)
OR 4.36 [3.53, 5.39]
6 studies · 2278 participants
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish was significantly better than CPP-ACP (SMD -0.78, 95% CI -1.33 to -0.24; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 1 year in permanent teeth, the effect of ACTIVA versus GIC on secondary caries is very uncertain (RR 22.80, 95% CI 0.89-584.17; very low certainty).
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 7.1% incidence in mandibular posterior teeth.
8 findings from 1 review
Proportion 7.1
1 study
GRADE not reported
Proportion 0
1 study
GRADE not reported
Proportion 6.1
1 study
GRADE not reported
Show 5 more findings
Proportion 9.4
1 study
GRADE not reported
Proportion 30.2
1 study
GRADE not reported
Proportion 23.7
1 study
GRADE not reported
Proportion 11.8
1 study
GRADE not reported
Proportion 7.5
1 study
GRADE not reported
Oral health-related quality of life · Indian elderly
One study found edentulism did not affect OHRQoL (dichotomous); ungraded.
3 findings from 1 review
Edentulism and QoL (dichotomous): edentulism did not affect OHRQoL (Shivakumar 2018). Single study, not pooled.
1 study
GRADE not reported
Edentulism and QoL (continuous, GOHAI/WHOQoL): one study reported edentulism negatively influenced QoL (Marina 2019), one found no effect (Appukuttan 2016). Not pooled.
2 studies
GRADE not reported
Edentulism and QoL (continuous, OHIP-14): no significant association between individuals with and without edentulism (Ajai 2020). Single study, not pooled.
1 study
GRADE not reported
Plaque · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
In randomized trials, clear aligners probably reduce plaque accumulation versus fixed appliances, though the subgroup estimate is imprecise and its CI crosses no effect (SMD -1.79, 95% CI -3.63 to 0.04; moderate certainty).
6 findings from 1 review
Show 3 more findings
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration was significantly better than fluoride varnish (SMD -0.70, 95% CI -1.18 to -0.21); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
The effect of MTA versus CH after pulpotomy is uncertain (low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth undergoing pulpotomy
The two trials of PRF versus MTA for success gave contradictory results and were not pooled (ungraded).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with undergraduate students was 5.68%.
2 findings from 1 review
Proportion 5.68 [3.17, 8.86]
1604 participants
GRADE not reported
Proportion 4.44 [2.16, 7.49]
2113 participants
GRADE not reported