Question · asked by 1 review
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline: Development of any (cavitated or non-cavitated) carious lesion
Preschool children with mutans streptococci at baseline probably have about four times higher odds of developing early childhood caries (OR 4.13; moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Overall Preschool children with mutans streptococci at baseline probably have about four times higher odds of developing early childhood caries (OR 4.13; moderate certainty). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 4.13 [3.33, 5.12] | 12 studies · 3010 participants | Moderate |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Sample: plaque When mutans streptococci were detected in plaque, baseline presence was associated with higher odds of developing caries (OR 5.16; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 5.16 [2.99, 8.91] | 5 studies · 736 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Sample: saliva When mutans streptococci were detected in saliva, baseline presence was associated with higher odds of developing caries (OR 3.92; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 3.92 [3.20, 4.80] | 9 studies · 2577 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 1 year, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Follow-up: 1 year At 1 year of follow-up, baseline mutans streptococci were associated with higher odds of developing caries (OR 4.37; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 4.37 [3.50, 5.45] | 4 studies · 2016 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 2.7 years (31 months median), Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Follow-up: 2.7 years (31 months median) At about 2.7 years (single study), baseline mutans streptococci were associated with higher odds of developing caries (OR 33.00, very wide CI; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 33.00 [3.18, 342.26] | 1 study · 28 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 2 years, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Follow-up: 2 years At 2 years of follow-up, baseline mutans streptococci were associated with higher odds of developing caries (OR 2.53; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 2.53 [1.22, 5.23] | 4 studies · 297 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Microbiological assessment: quantitative (culture/CFU counting) In studies using quantitative (culture-based) microbiological assessment, baseline mutans streptococci were associated with higher odds of developing caries (OR 3.82; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 3.82 [2.01, 7.26] | 6 studies · 732 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 3.5 years (42 months), Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Follow-up: 3.5 years (42 months) At 3.5 years (single study), baseline mutans streptococci were associated with higher odds of developing caries (OR 4.23; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 4.23 [2.49, 7.18] | 1 study · 366 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Follow-up: 6 months At 6 months of follow-up, baseline mutans streptococci were associated with higher odds of developing caries (OR 4.65; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 4.65 [2.01, 10.76] | 2 studies · 303 participants | GRADE not reported |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Caries-free preschool children (<6 y), primary dentition; community/clinic; studies from Japan, Finland, USA, Sweden and Singapore, Microbiological assessment: semi-quantitative (Dentocult/commercial kit) In studies using semi-quantitative (Dentocult/kit) microbiological assessment, baseline mutans streptococci were associated with higher odds of developing caries (OR 4.36; ungraded subgroup). Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) All outcomes | OR 4.36 [3.53, 5.39] | 6 studies · 2278 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and meta-analysis. 2023 All outcomes | 2022-11-15 | 23 | Not applicable |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Role of microbiological factors in predicting early childhood caries. · 2014 · included by 1 of these review
- Factors Associated with Caries Increment: A Longitudinal Study from 18 Months to 5 Years of Age · 2010 · included by 1 of these review
- Factors associated with caries increment: a longitudinal study from 18 months to 5 years of age. · 2010 · included by 1 of these review
- Caries Development in Children in Relation to the Presence of Mutans Streptococci in Dental Plaque and of Serum Antibodies against Whole… · 2009 · included by 1 of these review
- Caries Development in Children from 2.5 to 3.5 Years of Age: A Longitudinal Study · 2009 · included by 1 of these review
- Effect of mixed mutans streptococci colonization on caries development · 2006 · included by 1 of these review
- Effect of mixed mutans streptococci colonization on caries development. · 2006 · included by 1 of these review
- Evaluation of mutans streptococci in plaque and saliva: correlation with caries development in preschool children · 2003 · included by 1 of these review
- Evaluation of mutans streptococci in plaque and saliva: correlation with caries development in preschool children. · 2003 · included by 1 of these review
- Influence of colonization with mutans streptococci on caries risk in Japanese preschool children: 24 month survival analysis. · 2000 · included by 1 of these review
- Analysis of caries-related factors in infants and toddlers living in Sweden · 1996 · included by 1 of these review
- Analysis of caries-related factors in infants and toddlers living in Sweden. · 1996 · included by 1 of these review
- Caries experience and mutans streptococci as indicators of caries incidence. · 1996 · included by 1 of these review
- Multidimensional causal model of dental caries development in low-income preschool children. · 1995 · included by 1 of these review
- Caries development in children from 2.5 to 3.5 years of age: a longitudinal study. · 1995 · included by 1 of these review
- Caries prevalence and salivary mutans streptococci in 0–2‐year‐old children of Japan · 1991 · included by 1 of these review
- Caries prevalence and salivary mutans streptococci in 0-2-year-old children of Japan. · 1991 · included by 1 of these review
- Caries development in children in relation to the presence of mutans streptococci in dental plaque and of serum antibodies against whole… · 1990 · included by 1 of these review
- Streptococcus mutans establishment and dental caries experience in children from 2 to 4 years old · 1983 · included by 1 of these review
- Streptococcus mutans establishment and dental caries experience in children from 2 to 4 years old. · 1983 · included by 1 of these review
- Ansai et al. 2000 · included by 1 of these review
- Litt et al. 1995 · included by 1 of these review
- O'Sullivan and Thibodeau 1996 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.