Search review questions

Early childhood caries (ECC) - association with genetically predicted expression of TAS2R14 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), TAS2R14 (chr12p13.2); 48 (4) tissues; significant (Bonferroni p < 3.09x10-6)

Food choice · Children and adolescents aged 0-19 years · Overall (pooled across designs)

Restoration failure · Children with carious primary teeth · 2.5 years, Class II

Secondary/higher maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries · Secondary and higher education

Caries experience - mean dmfs (descriptive), primary dentition · CL/P vs no CL/P; Table 4 (6 groups/4 studies)

Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), Net-demineralizing conditions

Difference in summary sensitivity (NMA, Analysis 2) · Fluorescence vs Visual

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Data collection period: 2010-2014

Oral health-related quality of life (OHRQoL; ECOHIS/COHIP) · Children with dental caries (ages ~2-13 years in the pooled trials) · Post-treatment (follow-up varied by trial)

Dental caries (association with caregiver help with tooth brushing) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Restoration failure · Children with carious primary teeth · 1 year, Primary incisors

Restoration failure · Children with carious primary teeth · 1.5 years

Food choice · Children and adolescents aged 0-19 years · Nonrandomized studies

Color change of white spot lesion (color difference, T0 to T1) · Patients with post-orthodontic white spot lesions (permanent dentition, after removal of fixed multibracket… · 6 months

Dental caries (early childhood caries) · Healthy children under 6 years in South Africa

Enamel acid resistance / initiation of new enamel caries lesions (in vivo, narrative) · nHA vs non-fluoridated comparator: nHA significantly superior [25] (Polyakova 2020)

Caries prevalence · European adolescents aged 18 years · Exact age

Caries prevalence · European adolescents aged 15 years · Exact age

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: Nigeria

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: Kenya

External disease-state discrimination · Oral microbiome samples from four selected case-control studies

Difference in summary specificity (NMA, Analysis 2) · Imaging vs Visual

Lightness change · Patients with post-orthodontic white spot lesions and permanent dentition · 6 months

Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), IGSF5 (chr21q22.2); 27 (11) tissues; suggestive (p < 1.0x10-4) ; flagged possible false positive

Retention of sealant (complete or partial retention) · Children who were regular dental attenders with caries-free first or second primary molars (public health service… · 12 months

Caries experience · European adolescents aged 18 years · Exact age

Purchase requests · Children and adolescents aged 0-19 years · Randomized trials

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · 8-year follow-up, Upper incisors

Clinical and radiographic success rate (>=6 months) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure · >=6 months, Pulp capping material: MTA vs calcium hydroxide

Diet-related noncommunicable diseases · Children and adolescents aged 0-19 years

Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in… · Habitual daily intake

Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department,… · 24 months

Caries experience - mean dmft (descriptive), primary dentition · CL/P vs no CL/P; Table 4 (15 groups/13 studies)

Gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Plaque quantity (plaque index or plaque weight) · Adults and children (predominantly adults; one study in children), with natural dentition · End of study (last reported time point; study durations 4 days to 2 years), Sensitivity analysis (pre-post correlation set to 0.95 for the SFG group)

Oral health-related quality of life · Children with dental caries · Network estimate

Dental caries (association with low SES) · Children (deciduous and/or permanent dentition) in low- and middle-income countries · Low SES

Mean number of arrested caries surfaces · 38% SDF vs comparators (NaF/no treatment)

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Children using fluoride-containing dental care products (majority of included studies) · Habitual daily intake, Medium-fluoridated tap water (0.52-0.77 mg/L)

Restoration failure · Children with carious primary teeth · 1 year, Class II

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro) · Immediate bond strength, Caries-affected dentin (with rinsing step)

Dental caries (early childhood caries) · Healthy children under 6 years in South Africa

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · At least 24 months follow-up (3-12 years)

Treatment failure (annual failure rate) · Children with deep dentine caries in primary molars restored with composite resin (indirect pulp treatment; pulpotomy… · 36 months, Selective caries removal (SCR) arm

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: Eritrea

Dental caries measured by DMFS scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), >3 intervention activities

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: South Africa

HIV-related oral lesions · Children living with HIV receiving ART · CD4+ T-cell count below 250 cells/mm3

Mean caries increment (dmft) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric… · 12 months