Non-Cochrane · intervention · PM35227044
Bonding of Glass-Ionomer Cement and Adhesives to Silver Diamine Fluoride-treated Dentin: An Updated Systematic Review and Meta-Analysis.
Fröhlich Tatiana Tambara, Botton Graziela, Rocha Rachel de Oliveira · The journal of adhesive dentistry · 2022 · PubMed · doi:10.3290/j.jad.b2701679
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
10
current version
GRADE rated
0
No studies
0
Included studies
34
linked below
No studies 0 · 0%Ungraded 10 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Direct restorative materials (glass-ionomer cement and adhesives/resin composite) bonded to sound or caries-affected dentin, in vitro | Glass-ionomer cement (11 studies pooled) and adhesives (11 studies pooled) bonded to sound or caries-affected dentin; permanent, primary and bovine teeth |
| Intervention | Prior application of silver diamine fluoride to dentin | Prior SDF, mainly 30-38% (several with potassium iodide); 12% and 3.8% concentrations excluded from pooling |
| Comparison | No prior SDF application (untreated dentin) | Untreated dentin (no SDF) |
| Outcomes | Bond strength (MPa) | Immediate bond strength by microtensile (uTBS), microshear (uSBS) and shear (SBS) tests, in MPa |
| Study designs | In vitro studies with a control (untreated) group; studies without a control group, on root dentin, or using different restorative protocols between arms were excluded | 22 in vitro studies included (published 1993-2020, all in English); 21 pooled |
| Timing | Immediate bond strength | Immediate bond strength only (aging/long-term effects not meta-analyzable) |
Search date: Up to September 2020. Databases: PubMed/MEDLINE, ISI Web of Science, Scopus, LILACS; reference lists of included studies hand-searched
Questions and results
Prior application of silver diamine fluoride (SDF), with or without a rinsing step vs No prior SDF application (untreated dentin control)
Population: Glass-ionomer cement bonded to dentin (in vitro), sound or caries-affected
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Overall (all dentin conditions and rinsing protocols) Prior SDF application does not influence the immediate bond strength of glass-ionomer cement to dentin (MD -0.11 MPa, 95% CI -0.54 to 0.31; ungraded). Source: Fig 2 (forest plot, Total row); Results (Glass-ionomer cement); Abstract · same question in other reviews | MD -0.11 [-0.54, 0.31] | 11 studies · 583 participants | Ungraded |
Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)
Population: Glass-ionomer cement bonded to sound dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Sound dentin (without rinsing step) SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD 0.26 MPa, 95% CI -0.20 to 0.73; ungraded). Source: Fig 2 subgroup 1.1.1; Results (Glass-ionomer cement) · same question in other reviews | MD 0.26 [-0.20, 0.73] | 5 studies · 218 participants | Ungraded |
Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)
Population: Glass-ionomer cement bonded to sound dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Sound dentin (with rinsing step) SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD -1.11 MPa, 95% CI -3.47 to 1.25; ungraded). Source: Fig 2 subgroup 1.1.2; Results (Glass-ionomer cement) · same question in other reviews | MD -1.11 [-3.47, 1.25] | 4 studies · 57 participants | Ungraded |
Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)
Population: Glass-ionomer cement bonded to caries-affected dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Caries-affected dentin (without rinsing step) SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD 0.26 MPa, 95% CI -0.30 to 0.82; ungraded). Source: Fig 2 subgroup 1.1.3; Results (Glass-ionomer cement) · same question in other reviews | MD 0.26 [-0.30, 0.82] | 4 studies · 130 participants | Ungraded |
Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)
Population: Glass-ionomer cement bonded to caries-affected dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Caries-affected dentin (with rinsing step) SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD -0.36 MPa, 95% CI -1.07 to 0.35; ungraded). Source: Fig 2 subgroup 1.1.4; Results (Glass-ionomer cement) · same question in other reviews | MD -0.36 [-1.07, 0.35] | 5 studies · 178 participants | Ungraded |
Prior application of silver diamine fluoride (SDF), with or without a rinsing step vs No prior SDF application (untreated dentin control)
Population: Dental adhesives/resin composite bonded to dentin (in vitro), sound or caries-affected
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Overall (all dentin conditions and rinsing protocols) Prior SDF application significantly reduces the immediate bond strength of adhesives to dentin overall (MD 7.12 MPa favoring untreated dentin, 95% CI 1.38 to 12.85; ungraded), with very high heterogeneity (I2=98%). Source: Fig 3 (forest plot, Total row); Results (Adhesives); Abstract · same question in other reviews | MD 7.12 [1.38, 12.85] | 11 studies · 526 participants | Ungraded |
Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)
Population: Dental adhesives bonded to sound dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Sound dentin (without rinsing step) Prior SDF without a rinsing step significantly reduces adhesive bond strength to sound dentin (MD 17.52 MPa favoring untreated dentin, 95% CI 5.81 to 29.22; ungraded). Source: Fig 3 subgroup 1.1.1; Results (Adhesives) · same question in other reviews | MD 17.52 [5.81, 29.22] | 3 studies · 136 participants | Ungraded |
Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)
Population: Dental adhesives bonded to sound dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Sound dentin (with rinsing step) A rinsing step after SDF eliminates the negative effect on adhesive bond strength to sound dentin (MD 7.11 MPa, 95% CI -0.57 to 14.79, non-significant; ungraded). Source: Fig 3 subgroup 1.1.2; Results (Adhesives) · same question in other reviews | MD 7.11 [-0.57, 14.79] | 7 studies · 318 participants | Ungraded |
Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)
Population: Dental adhesives bonded to caries-affected dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Caries-affected dentin (with rinsing step) Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded). Source: Fig 3 subgroup 1.1.3; Results (Adhesives) · same question in other reviews | MD -4.79 [-9.19, -0.40] | 3 studies · 72 participants | Ungraded |
Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)
Population: Dental adhesives bonded to caries-affected dentin (in vitro)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immediate bond strength (MPa) Immediate bond strength · Caries-affected dentin (without rinsing step) Only one study assessed SDF without a rinsing step on adhesive bonding to caries-affected dentin (Kucukyilmaz 2016, which reported impaired bond strength); no meta-analysis was possible, so no pooled estimate is available. Source: Discussion (adhesives, caries-affected without rinsing); Table 2 · same question in other reviews | no estimate extracted | 1 study | Ungraded |
AMSTAR 2 appraisal
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | No | no |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | No | No | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: N/A · NRSI: Partial Yes | NRSI: No · RCT: N/A | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: N/A · NRSI: Yes | NRSI: No · RCT: N/A | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |
Included primary studies 34
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Siqueira et al, 2020 Effect of Silver Diamine Fluoride on the Bonding Properties to Caries-affected Dentin. PMID:32322837 | 1 other review | not stated | not extracted yet | not extracted yet |
| Van Duker 2019 Effect of silver diamine fluoride and potassium iodide on bonding to demineralized dentin. PMID:31295396 | 1 other review | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Braz 2020 The effect of silver diamine fluoride and cleaning methods on bond strength of glass-ionomer cements to caries-affected dentin. PMID:32794394 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Firouzmandi 2020 Effect of silver diamine fluoride on the bond durability of normal and carious dentin. PMID:32509229 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Francois 2020 Shear bond strength and interfacial analysis of high-viscosity glass ionomer cement bonded to dentin with protocols including silver… DOI:10.2334/josnusd.20-0065 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| François et al, 2020 Shear bond strength and interfacial analysis of high-viscosity glass ionomer cement bonded to dentin with protocols including silver… PMID:32879159 | this review only | not stated | not extracted yet | not extracted yet |
| Gupta 2019 Effect of silver diamine fluoride-potassium iodide and 2% chlorhexidine gluconate cavity cleansers on the bond strength and microleakage… PMID:31142994 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Jiang 2020 Influence of Silver Diamine Fluoride Treatment on the Microtensile Bond Strength of Glass Ionomer Cement to Sound and Carious Dentin DOI:10.2341/19-237-l | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Jiang et al, 2020 Influence of Silver Diamine Fluoride Treatment on the Microtensile Bond Strength of Glass Ionomer Cement to Sound and Carious Dentin. PMID:32502257 | this review only | not stated | not extracted yet | not extracted yet |
| Knight 2006 The effect of silver fluoride and potassium iodide on the bond strength of auto cure glass ionomer cement to dentine DOI:10.1111/j.1834-7819.2006.tb00399.x | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Knight et al, 2006 The effect of silver fluoride and potassium iodide on the bond strength of auto cure glass ionomer cement to dentine. PMID:16669476 | this review only | not stated | not extracted yet | not extracted yet |
| Ko 2020 Effect of silver diammine fluoride application on dentin bonding performance DOI:10.4012/dmj.2019-057 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Ko et al, 2020 Effect of silver diammine fluoride application on dentin bonding performance. PMID:31932548 | this review only | not stated | not extracted yet | not extracted yet |
| Koizumi 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Kucukyilmaz 2016 Effect of silver diamine fluoride and ammonium hexafluorosilicate applications with and without Er:YAG laser irradiation on the… DOI:10.1002/lsm.22439 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Kucukyilmaz et al, 2016 Effect of silver diamine fluoride and ammonium hexafluorosilicate applications with and without Er:YAG laser irradiation on the… PMID:26729655 | this review only | not stated | not extracted yet | not extracted yet |
| Lutgen 2018 Effects of silver diammine fluoride on bond strength of adhesives to sound dentin DOI:10.4012/dmj.2017-401 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Lutgen et al, 2018 Effects of silver diammine fluoride on bond strength of adhesives to sound dentin. PMID:30224603 | this review only | not stated | not extracted yet | not extracted yet |
| Markham 2020 Influence of 38% silver diamine fluoride application on bond stability to enamel and dentin using universal adhesives in self‐etch mode DOI:10.1111/eos.12701 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Markham et al, 2020 Influence of 38% silver diamine fluoride application on bond stability to enamel and dentin using universal adhesives in self-etch mode. PMID:32395905 | this review only | not stated | not extracted yet | not extracted yet |
| Ng 2020 Shear Bond Strength of Glass Ionomer Cement to Silver Diamine Fluoride-Treated Artificial Dentinal Caries. PMID:32522327 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Puwanawiroj 2018 Microtensile Bond Strength Between Glass Ionomer Cement and Silver Diamine Fluoride-Treated Carious Primary Dentin. PMID:30345969 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Quock 2012 Effect of Silver Diamine Fluoride on Microtensile Bond Strength to Dentin DOI:10.2341/11-344-l | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Quock et al, 2012 Effect of silver diamine fluoride on microtensile bond strength to dentin. PMID:22621162 | this review only | not stated | not extracted yet | not extracted yet |
| Selvaraj 2016 Evaluation of microshear bond strength and nanoleakage of etch-and-rinse and self-etch adhesives to dentin pretreated with silver diamine… DOI:10.4103/0970-9290.191893 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Selvaraj et al, 2016 Evaluation of microshear bond strength and nanoleakage of etch-and-rinse and self-etch adhesives to dentin pretreated with silver diamine… PMID:27723641 | this review only | not stated | not extracted yet | not extracted yet |
| Siqueira 2020 DOI:10.3290/j.jad.a44281 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Uchil 2020 Effect of three silver diamine fluoride application protocols on the microtensile bond strength of resin-modified glass ionomer cement to… DOI:10.4103/jisppd.jisppd_159_20 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Uchil et al, 2020 Effect of three silver diamine fluoride application protocols on the microtensile bond strength of resin-modified glass ionomer cement to… PMID:32611859 | this review only | not stated | not extracted yet | not extracted yet |
| Wang 2016 matched by author and year (probable) | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Wu 2016 Effect of Silver Diamine Fluoride (SDF) Application on Microtensile Bonding Strength of Dentin in Primary Teeth. PMID:27097864 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
| Yamaga 1993 Adhesiveness of Glass Ionomer Cement Containing Tannin-Fluoride Preparation (HY agent) to Dentin DOI:10.4012/dmj.12.36 | this review only | not stated | not extracted yet | not extracted yet |
| Yamaga et al, 1993 [Cardiac mechanisms for the development of angina pectoris pain]. PMID:3066041 | this review only | not stated | not extracted yet | not extracted yet |
| Zhao 2019 Effect of silver diamine fluoride and potassium iodide on shear bond strength of glass ionomer cements to caries-affected dentine. PMID:30892699 | this review only | Immediate bond strength (MPa) | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).
| Review | Shared studies | Jaccard |
|---|---|---|
| Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | 2 | 0.04 |